ID C5KU21_PERM5 Unreviewed; 448 AA.
AC C5KU21;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=adenosine kinase {ECO:0000256|ARBA:ARBA00012119};
DE EC=2.7.1.20 {ECO:0000256|ARBA:ARBA00012119};
GN ORFNames=Pmar_PMAR019169 {ECO:0000313|EMBL:EER12063.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER12063.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC from adenosine: step 1/1. {ECO:0000256|ARBA:ARBA00004801}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000256|ARBA:ARBA00010688}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG676180; EER12063.1; -; Genomic_DNA.
DR RefSeq; XP_002780268.1; XM_002780222.1.
DR AlphaFoldDB; C5KU21; -.
DR EnsemblProtists; EER12063; EER12063; Pmar_PMAR019169.
DR GeneID; 9060975; -.
DR InParanoid; C5KU21; -.
DR OrthoDB; 5475204at2759; -.
DR UniPathway; UPA00588; UER00659.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0004001; F:adenosine kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1110.10; -; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR001805; Adenokinase.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR PANTHER; PTHR45769; ADENOSINE KINASE; 1.
DR PANTHER; PTHR45769:SF3; ADENOSINE KINASE; 1.
DR Pfam; PF00294; PfkB; 2.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EER12063.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine salvage {ECO:0000256|ARBA:ARBA00022726};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 109..208
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
FT DOMAIN 275..374
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 448 AA; 48592 MW; 1CDAEF67821A5C99 CRC64;
MATSASPSAV AVDAVASCDD SSSISATLST YDDSEVASLL SSSRQHLEGI ITNDMPTSIV
GLCHPLLDLV ATIDDFEAYG LEPSTQRLAK GSDEDKKLFA RMLGDGELTV HRIAGGQAMN
SLRGVKWWFD RHEADPEYND VSFANTSVRI VGSVGDDEYA NVLREACVEA GLETDFEVFP
GGRTGKCCAL LKDKKRTMIT DLGVAPDFRA GPERGIPTDC RILYTTAFYA CGDGYACREY
IPNHPQIKSG YTKLFAGLSA AWACKNDDFT YMARYACDVV FGNEVEFTAF AEHLGIVGVS
KMSPREIAEA VSAFMKPGAW AIMTQGPDPV VCCSNLTDTC DAFTHTVRDL DPLAISDDIG
AGDGFVGGFI AAIYARLLAS DFTPRSVPSP VESIISNARD DDTSYLLPGD DSRSDTWYWI
TRQMVMDGVE EGIYCARQVM KHTGCQYF
//
