ID C5L183_PERM5 Unreviewed; 295 AA.
AC C5L183;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=3-hydroxyacyl-CoA dehyrogenase, putative {ECO:0000313|EMBL:EER09490.1};
GN ORFNames=Pmar_PMAR016421 {ECO:0000313|EMBL:EER09490.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER09490.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
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DR EMBL; GG678232; EER09490.1; -; Genomic_DNA.
DR RefSeq; XP_002777674.1; XM_002777628.1.
DR AlphaFoldDB; C5L183; -.
DR EnsemblProtists; EER09490; EER09490; Pmar_PMAR016421.
DR GeneID; 9052386; -.
DR InParanoid; C5L183; -.
DR OMA; MRLGCNQ; -.
DR OrthoDB; 314530at2759; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006180; 3-OHacyl-CoA_DH_CS.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00067; 3HCDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800}.
FT DOMAIN 17..192
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 200..295
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 154
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
SQ SEQUENCE 295 AA; 31723 MW; 1BEA493BF9E9DA76 CRC64;
MLSRFTRPLY STISRLNVIG AGQMGTGIGI VAARYGKCAV TMMDNSAEAL KKSEKFVEGW
LGKEISKGRM SADDVTAFHS LVSFASVESK QALDSCDMVI EAVVENIAVK GPLFGMLSEI
VKPECILGTN TSSISITKIA AYAKGMEDKV IGTHFMLPVP VMKLVEVIRG LSTSDATHAT
TLDFVASLGK TAATSLDRPG FIANRLLMPY INEAIICLQD GVSSKEDIDT IMKLGTNVPL
GPLALADLIG LDTCLFIMQV LHRELGDKYR PAPLLQMHVD AGHLGKKTGQ GFYTY
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