ID C5L7H4_PERM5 Unreviewed; 618 AA.
AC C5L7H4;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Branchpoint-bridging protein {ECO:0000256|RuleBase:RU367126};
GN ORFNames=Pmar_PMAR020598 {ECO:0000313|EMBL:EER07436.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER07436.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for the splicing of pre-mRNA. Has a role in the
CC recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract
CC and the 3'-splice site at the 3'-end of introns.
CC {ECO:0000256|RuleBase:RU367126}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367126}.
CC -!- SIMILARITY: Belongs to the BBP/SF1 family.
CC {ECO:0000256|ARBA:ARBA00010382, ECO:0000256|RuleBase:RU367126}.
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DR EMBL; GG679899; EER07436.1; -; Genomic_DNA.
DR RefSeq; XP_002775620.1; XM_002775574.1.
DR AlphaFoldDB; C5L7H4; -.
DR EnsemblProtists; EER07436; EER07436; Pmar_PMAR020598.
DR GeneID; 9041180; -.
DR InParanoid; C5L7H4; -.
DR OrthoDB; 1397at2759; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0045131; F:pre-mRNA branch point binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:UniProtKB-UniRule.
DR CDD; cd00105; KH-I; 1.
DR Gene3D; 6.10.140.1790; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR InterPro; IPR045071; BBP-like.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR InterPro; IPR032570; SF1-HH.
DR InterPro; IPR047086; SF1-HH_sf.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR PANTHER; PTHR11208; RNA-BINDING PROTEIN RELATED; 1.
DR PANTHER; PTHR11208:SF45; SPLICING FACTOR 1; 1.
DR Pfam; PF16275; SF1-HH; 1.
DR SMART; SM00322; KH; 2.
DR SMART; SM00343; ZnF_C2HC; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR PROSITE; PS50084; KH_TYPE_1; 2.
DR PROSITE; PS50158; ZF_CCHC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367126};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU367126};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|RuleBase:RU367126};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367126};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117};
KW Spliceosome {ECO:0000256|RuleBase:RU367126};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367126};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00047}.
FT DOMAIN 309..325
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT REGION 100..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 618 AA; 68574 MW; B1CE473DC034B2E7 CRC64;
MSEEIISTDG GYQIVPVVGA DAGGIIMIAG KRRKRDTRWG PRKHIKLGKR LSTVDDKPYK
PLPLLDVPCG LGWKQIDQMM REIRLEDCTM DNKLRAEPIR LELGDPDIRP PSPPPTYDQL
GTRTNDRTTR VKKAMEGEHN RLVRYMMATV RDYIPPETWN KARLVRKIII PQKKYPDVPF
MAIIVGARGT NHKRLQMESG CRIEIRGKGI NAMNQTIEEQ NMPQHVHIEG DTEVNLIKAT
ALLEPLLDPT HPDFARARAL GLEQLAVVNG YTTQVQHIRC GLCQAMGHHA SQCPEFNNVE
MSYKMADVKC DICGDKGHAT IDCPQKGTAQ QKSKEWREEA EERAKVDQEY ADLINNLAEE
NDPLKSGGLQ NGSTGSIEED GNEILIPFKD VDQSNKDARN CPVQITGPAG AIEQAKEKIR
EWLKNREAGA NAQIPMVLGV PGDEEPIRLP ATLVGVFIGH NSQNLKALER DLGVGLMLDG
KKESGILDHP VLFSGSDEAI LEAKPKLREW ISQRMVTPQG EAGFGQVLPE FPGFPGGFPF
PPAPGAAAAA YMPMMMGMMG APPQGMMPAG YPQMQQTFAP PPPPVSGGQY QVPAMDQASW
QLLYQQRLQQ EQMQYRPQ
//
