ID C5LJM6_PERM5 Unreviewed; 1357 AA.
AC C5LJM6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Succinate dehydrogenase, putative {ECO:0000313|EMBL:EER03043.1};
GN ORFNames=Pmar_PMAR001788 {ECO:0000313|EMBL:EER03043.1};
OS Perkinsus marinus (strain ATCC 50983 / TXsc).
OC Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC Perkinsus.
OX NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN [1] {ECO:0000313|EMBL:EER03043.1, ECO:0000313|Proteomes:UP000007800}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the cytochrome b5 family.
CC {ECO:0000256|ARBA:ARBA00038168}.
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DR EMBL; GG682469; EER03043.1; -; Genomic_DNA.
DR RefSeq; XP_002771227.1; XM_002771181.1.
DR EnsemblProtists; EER03043; EER03043; Pmar_PMAR001788.
DR GeneID; 9051709; -.
DR InParanoid; C5LJM6; -.
DR Proteomes; UP000007800; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 6.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 1.20.1300.10; Fumarate reductase/succinate dehydrogenase, transmembrane subunit; 1.
DR Gene3D; 3.90.700.10; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR018506; Cyt_B5_heme-BS.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR010960; Flavocytochrome_c.
DR InterPro; IPR034804; SQR/QFR_C/D.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR NCBIfam; TIGR01813; flavo_cyto_c; 1.
DR PANTHER; PTHR19359; CYTOCHROME B5; 1.
DR Pfam; PF00173; Cyt-b5; 6.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SMART; SM01117; Cyt-b5; 6.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 6.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF81343; Fumarate reductase respiratory complex transmembrane subunits; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
DR PROSITE; PS00191; CYTOCHROME_B5_1; 6.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 6.
PE 3: Inferred from homology;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1093..1112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1133..1154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1174..1198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1210..1233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1276..1297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1317..1339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 427..503
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 532..608
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 629..705
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 736..812
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 837..913
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT DOMAIN 968..1044
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 716..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 926..940
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1357 AA; 145586 MW; 3CD1C6460037F1D5 CRC64;
MVEHSGPSVN WLMDVFGLDL SLLSRLGGHS VERTHRGKER FPGMTITYAE MQMAEAIAKA
HPDKCQIINK ARATELETDN EGNVIGVKYE KDGKSYVVDG PVILATGGYG ADFTKDGLLA
KYRPDLLKLS TTNGEHCTGD GIKMGVAADA DVVDLEWVQV HPTGLVNPKD PDSKVKFLAA
EALRGVGGIL LDADGHRFSN ELGRRDYVSD RMFHNKGPFR LVLNTASANE IRWHVEHYKG
RGVMKDFDSA YDLAKEMGIP ASTLEQTFKD YKEVASKQEA NPDGGEYDAY PTGKTFDKFG
KKFFTNYDFK MDDHYSVAIV TPLVHYCMGG LKIDTAGRVI SKETKKPIRG LYAAGEVMGG
VHGNNRLGGN SLLDCVVFGR LTADDACEGL LGLKKSVSLP ALAKAPASVP KKVAQAKVAA
APAAPVVHGY TKEEVAKHTT ESDCWVIING QVLNVTNFLP EHPGGKLAIM TFAGKDASKE
FNMIHPSDVI EKYAPDCVLG PVVDKATAAA APVAPAAPAA VTVTPTNSAA AGKSYTMEEI
SKHNSRESCW VVIDGEVLDV TGFLPDHPGG DISILNYGGK DATEPFHDIH PAGIIQKYCP
DAVIGVVGTG SAAPSTVSTA PASAPAPAVS GYTKEEVAKH ITESDCWVII NGQVLNVTNF
LPEHPGGKLA IMTFAGKDAT KEFNMIHPAD VIEKYASECV LGPVVEANSA PAVAATSAPA
APTAVTTTPT TSGAAGKSYT MDEISKHNSR ESCWVVIDGE VLDVTDFLPD HPGGDISILN
FGGRDATGPF HDIHPAGIIQ KYCPDAVIGV VGTGSAAPST ASTAPASAAA SAPAPAVSGY
TMDEVAKHTT EDDCWVAING QVLNVTDFLP EHPGGKLAIM TFAGKDATKE FNMIHPPDVI
EKYASECVLG PVIEGKSAPA PVASTPAPVA STPAPAPVAS KPAPATSTAA STPAPTPVAP
VVATSAAASG ITMDEVAKHT TEDDCWVVIN GEVLDVTDFL PKHPGGKMAI LTFAGKDASK
EFNMIHPAGV IAKYAPDATL GPLVEKTAGP AAAGGDLSQP LLADQFESKA LTEQWWGEDR
NKSDMFGPLG PSISSYAISL CYLIWMFVID TLKTIFSVKN YKVLSDKSGL QRSAIFMMVF
VTIHALGNIN LLVGDRNFEG YAYLLNHPCP WSTLFLPVEI YLLLAGILHV VVATVRTFKF
KSMNSSFRDL EMFITGCILL IFLIVHLIQF RFVSEASAPK YWMRDNWFPC ADDDTSCPII
HFKDLYKMAF QIFESFGWVC FYIVGVIAFF IHMKSGLSRV IMTNGNIPRK YKSTTQFWGS
VMSWVLFLLY LTYPLFAYFN PVKDWAAYDA KQIRPKF
//
