ID   C5LV85_PERM5            Unreviewed;       681 AA.
AC   C5LV85;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE            EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN   ORFNames=Pmar_PMAR027985 {ECO:0000313|EMBL:EEQ99323.1};
OS   Perkinsus marinus (strain ATCC 50983 / TXsc).
OC   Eukaryota; Sar; Alveolata; Perkinsozoa; Perkinsea; Perkinsida; Perkinsidae;
OC   Perkinsus.
OX   NCBI_TaxID=423536 {ECO:0000313|Proteomes:UP000007800};
RN   [1] {ECO:0000313|EMBL:EEQ99323.1, ECO:0000313|Proteomes:UP000007800}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50983 / TXsc {ECO:0000313|Proteomes:UP000007800};
RA   El-Sayed N., Caler E., Inman J., Amedeo P., Hass B., Wortman J.;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG685819; EEQ99323.1; -; Genomic_DNA.
DR   RefSeq; XP_002766606.1; XM_002766560.1.
DR   AlphaFoldDB; C5LV85; -.
DR   EnsemblProtists; EEQ99323; EEQ99323; Pmar_PMAR027985.
DR   GeneID; 9045503; -.
DR   InParanoid; C5LV85; -.
DR   OrthoDB; 179296at2759; -.
DR   Proteomes; UP000007800; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR010644; ChdC/CLD.
DR   InterPro; IPR011008; Dimeric_a/b-barrel.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   PANTHER; PTHR24356; SERINE/THREONINE-PROTEIN KINASE; 1.
DR   PANTHER; PTHR24356:SF184; SERINE_THREONINE-PROTEIN KINASE TRICORNERED; 1.
DR   Pfam; PF06778; Chlor_dismutase; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF54909; Dimeric alpha+beta barrel; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   4: Predicted;
KW   Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Kinase {ECO:0000313|EMBL:EEQ99323.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007800};
KW   Transferase {ECO:0000313|EMBL:EEQ99323.1}.
FT   DOMAIN          290..549
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
SQ   SEQUENCE   681 AA;  77526 MW;  1D49531D1462D4E0 CRC64;
     MSSSPTDTTK AISDLPMAPL AIAGSVAAAL SAGVLIYRHR HQELPLPRSL RRIAPALLTR
     AGGQAESAHF KMPVFDGPVL YEKGANGQKM DKRLYCQLYV LDCINAAKLP EAREKLQLEL
     VRRNIPSVIY DDVNSPKTIG LLTWSEDPKH FPTVVNPVLQ LEGIGDVLEP RQGWTMLGKT
     YSSGHEADLG DYLLQKVIRN VTMKDTEYAI WYPMRREGKF SMEKPGDQCQ MLLQHAAIGK
     AYSKVGAWDV RLNCYGLDAA DNEFVIGLVH KELNPLSKLV EDMRKTEHTA LFMKSLGPFF
     VGHRVFVREK STGNIYAMKQ MRKKDMDRKK QVHHVLAERD VLALAHTDWV IDLKYTFMDK
     HFLYMVMEYL PGGDLMTHMI RKDKFTEEET RFYVAELVQA VDYIHTSLSY IHRDVKPDNI
     LFDARGHIKL LDFGLSKYHP DLVTNLAGTP DYMAPEVFSG TGYDESIDWW SVGVIMYEML
     FGGPPFSNET HDPLVTSRRV QNWRRYFHIP TSNGGCSPEA EDLLRRLICD AKDRLSFFSA
     DAIRAHPLFA GLDWDHLREL EAPINETDTQ NFDDFPEEMH AGTHAFPSQG GAESRDRVDY
     ITHYLFAHAE LISGHLPMAP VAKNDRYSES DVLEIFKLPS RPRGGGEVVV NLERIANTLM
     SHLLTRDLLL RERRIHSERR I
//