ID C5M6G0_CANTT Unreviewed; 1028 AA.
AC C5M6G0;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN ORFNames=CTRG_01441 {ECO:0000313|EMBL:EER34580.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER34580.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER34580.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; GG692396; EER34580.1; -; Genomic_DNA.
DR RefSeq; XP_002547135.1; XM_002547089.1.
DR AlphaFoldDB; C5M6G0; -.
DR STRING; 294747.C5M6G0; -.
DR EnsemblFungi; CTRG_01441-t43_1; CTRG_01441-t43_1-p1; CTRG_01441.
DR GeneID; 8301329; -.
DR KEGG; ctp:CTRG_01441; -.
DR VEuPathDB; FungiDB:CTRG_01441; -.
DR eggNOG; KOG2126; Eukaryota.
DR HOGENOM; CLU_004298_1_0_1; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 505..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 609..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..696
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..766
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..861
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 917..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 953..976
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 988..1013
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1028 AA; 116713 MW; 45A18908432E7F68 CRC64;
MTDENGITRR SMSPTQQQQQ PIMHTQAQQQ AQSFAKDPRL QPPTRTRIRQ QKLKYTFVGY
IIVLIFLAIT QVIGVLFFKE GFLLSRTVLP NISTCKEQND CMNPRFEKAI FLVIDALRFD
FVIPIPGSEE YYHNNFPILY DLANSKSDHA VLLKFMADPP TTTLQRLKGL TTGSLPTFID
AGSNFDGDAI DEDNWLLQLH RINKTIAFMG DDTWKALFSE YIHPDYNFPY DSLNVWDLHT
VDNGVIEHMY PLISKENCTK WDLLVGHFLG VDHVGHRYGP RHYSMKEKLN QMNDVVTKVI
KSMDDKTLLV IIGDHGMDST GNHGGDSKDE LESTLFMYSK SKKFLKKDKS HYNITDMGKN
YRSVNQIDLV PTMSLLLGLP IPYNNLGFPI DEAFGSIKEL STASQKTIDQ IKKFRKDTPS
LSDSLLEEYD SYNSNYDTFG ASKKHFSNLI EQAKLYQYLS LEQCKGLWAT FDLRFIGIGL
GILFLSLTFM ITYSRSIPAV RVSTMSFEFI GSVIAMSIMG LVLSFSIFIV LKPGDFTLNI
CLSIGAALGM VIGFWAPIMD RFSVGFLWHQ TIDFFLYNFN SWSFMGIVFV AFHCLIFASN
SYVVWEDKMV QFFLLTFGGT CIYACYTSNK LSEKAKVLAL SHAITFTMCT RLASMINLCR
EEQRPYCTPT FATSWWSILL LHLVAYLLPA CIKSFYHLSD SYHSAAPLWI GTGLKFLLFM
NAVYWTFEFV STNEYFSKIN LLIGTSLLVS FKLAIARLVL FISLVLANFS WSRGPLCVKL
ELSNSANNSI HLEETDDDDN SDSDSSNNKT ATILGYGNVY GSSYFLLVLN FTVAIMLTTK
PIGALSISLL IVQILSLLEI LDVLEIRKNL ITPIIFGLLG YQHFFSTGHQ ATLQSIQWEM
GFMTTETIVF PFTHLNIFLN TMGPFLLTGL AIPLITIWKI IPSSKPITLL SQIITNITTL
ITYHLFTGLS SLLFAAHFRR HLMVWKIFAP RFMLSGILII SLNIFLIFIT LWFGTGRILS
QINRIFGK
//
