ID   C5ME66_CANTT            Unreviewed;       710 AA.
AC   C5ME66;
DT   28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT   28-JUL-2009, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Calcineurin-like phosphoesterase domain-containing protein {ECO:0000259|Pfam:PF00149};
GN   ORFNames=CTRG_04358 {ECO:0000313|EMBL:EER31576.1};
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747 {ECO:0000313|EMBL:EER31576.1, ECO:0000313|Proteomes:UP000002037};
RN   [1] {ECO:0000313|EMBL:EER31576.1, ECO:0000313|Proteomes:UP000002037}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA   Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA   Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA   Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA   Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA   Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA   Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
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DR   EMBL; GG692400; EER31576.1; -; Genomic_DNA.
DR   RefSeq; XP_002550061.1; XM_002550015.1.
DR   AlphaFoldDB; C5ME66; -.
DR   STRING; 294747.C5ME66; -.
DR   EnsemblFungi; CTRG_04358-t43_1; CTRG_04358-t43_1-p1; CTRG_04358.
DR   GeneID; 8296779; -.
DR   KEGG; ctp:CTRG_04358; -.
DR   VEuPathDB; FungiDB:CTRG_04358; -.
DR   eggNOG; KOG3770; Eukaryota.
DR   HOGENOM; CLU_014743_2_0_1; -.
DR   OrthoDB; 205363at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd00842; MPP_ASMase; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR041805; ASMase/PPN1_MPP.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   PANTHER; PTHR10340:SF27; ASMASE_C DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR10340; SPHINGOMYELIN PHOSPHODIESTERASE; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002037};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..710
FT                   /note="Calcineurin-like phosphoesterase domain-containing
FT                   protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002955209"
FT   DOMAIN          339..544
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
SQ   SEQUENCE   710 AA;  83412 MW;  0DE928C22E44BB43 CRC64;
     MMLVQEIVLV FATLTVLIQS HTIPGLGSLH IQDDLSKRAN LIDPVYENLK DSEIDFINTH
     MTNLTNYNTT SDCDSCKFRL RYAKSLIDDY PDQSHLTSLL LFKYCIESNK GKEDKCDHVD
     FFVTTDSKNF DKFDDDFDSG IAQVGGLNFY DNDFLHMLKN FNLSNELDME YYCYFKQKGA
     CDLPETPDVE ELFGISKWWP EKEPHQYFEP NYTNNSEIFN VLHLSDIHIQ LKYDLGSETN
     CTQDVCGLKE AYNDELPGKN YNFTDYYKSF NPEMTNMQFS FYPDAHYDEN DQYIKGEYYD
     YPKYRGWNFN FIPATSFGAY LSDSPEILMN NSLIHMANVH KDKNFEFAIF TGDVVDHLVE
     SCTPEYTKEE EIRSFKAMKH FFGNIPVLPA LGNHENFNYG QLSPLRYDLN HTYDWNENEM
     VDLWVNNEWF DEKDAEDLKS HYAGFSYVTN RGLKVIGLNS NAFYQKNLWS YINHTTEADL
     FGQWSFLVDE LLASERKGQR VWIMAHIPTS DYDALPIQSR IFGKIVERFS PYTIANIFYG
     HTHQDQFHIY YSSNSSQEAE DIINMSWVLQ SITPMAFYNP SWRYYEVQHE SFNIMNSYNY
     YTLLNETFVN GGAEPIWRFE YSARDLYDPE HTWPTDAPLN ATFWHKYVAT QLKNETNIEF
     NQKFLEIQYR YGPGVTDCDN NGTVSDDCYN QNYCVVGNFF SDDYQNCLRY
//