ID C5MFV6_CANTT Unreviewed; 649 AA.
AC C5MFV6;
DT 28-JUL-2009, integrated into UniProtKB/TrEMBL.
DT 28-JUL-2009, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN ORFNames=CTRG_04949 {ECO:0000313|EMBL:EER31219.1};
OS Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=294747 {ECO:0000313|EMBL:EER31219.1, ECO:0000313|Proteomes:UP000002037};
RN [1] {ECO:0000313|EMBL:EER31219.1, ECO:0000313|Proteomes:UP000002037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-3404 / T1 {ECO:0000313|Proteomes:UP000002037};
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W., Harris D., Hoyer L.L., Hube B., Klis F.M.,
RA Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M., Nikolaou E.,
RA Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F., Sherlock G.,
RA Shah P., Silverstein K.A., Skrzypek M.S., Soll D., Staggs R.,
RA Stansfield I., Stumpf M.P., Sudbery P.E., Srikantha T., Zeng Q., Berman J.,
RA Berriman M., Heitman J., Gow N.A., Lorenz M.C., Birren B.W., Kellis M.,
RA Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG692401; EER31219.1; -; Genomic_DNA.
DR RefSeq; XP_002550651.1; XM_002550605.1.
DR AlphaFoldDB; C5MFV6; -.
DR STRING; 294747.C5MFV6; -.
DR EnsemblFungi; CTRG_04949-t43_1; CTRG_04949-t43_1-p1; CTRG_04949.
DR GeneID; 8299022; -.
DR KEGG; ctp:CTRG_04949; -.
DR VEuPathDB; FungiDB:CTRG_04949; -.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_016108_1_0_1; -.
DR OrthoDB; 25175at2759; -.
DR Proteomes; UP000002037; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR PANTHER; PTHR15228:SF25; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 2.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002037}.
FT DOMAIN 189..497
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 25..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 509..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 391..425
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 25..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 318..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 70661 MW; 29BA489061B8CDCC CRC64;
MSHSSSPNNR SSIFGWAKSL KKSHFLSSES VNEISDNESL GKSPTKSMIF NPNFNGSGSG
SGSGSGNGAS QPQNIPLPPQ GSTSSLFNNH PSSPPPHSNS HHHNIQPSSI TNYLSTSPTP
GSDFLRPLLN PRSRSANNVS RVRSNSLNQS ETNSVRQHRD SFLQSNSLLD ENSKYFGVPL
QQALNEASAK ISILATEQGD GLNYGQIPIV VAKCGVYLKK NGLTVEGIFR VGGSSKRIKE
LQVIFNTPPN YGKKLNWDGF TVHDAASVLR RYLNALPEPL IPLDMYELFR EPLRSRNRII
SYMKYKAENP AKSLPSKDAA IATSNSSISR PSLPQNGTNN NANNSTSDLL DSSQLLTEAN
VGRLNGDNAP RKNSEGSSNI FSQTPQVQLS EEEINIRNKK KSKNYKKLTN EIHSAIDEYK
SLVNALPVAS KQLLFYILDL LAMVQNHSKE NLMSSRNLAA IFQPSILSHP SHDLDPIEYA
LSQSVVEFLI QYAYKLLPNH EATVLSPEAT SPTTKSAMPT HISTNTANFA PTESDVTSTS
TSPLGEEAHL TKDAFPHVPP PRHHSISSGP NNDDLVSGYQ HNVTGSLPFD SDMESDIGSD
LDELHFQQLK LNEGSPIKFN QKSSSPPVPN AIVVSTPSSS SVPLVKHEI
//
