ID C5NZJ5_COCP7 Unreviewed; 750 AA.
AC C5NZJ5;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 58.
DE SubName: Full=Ketopantoate reductase PanE/ApbA family protein {ECO:0000313|EMBL:EER29888.1};
GN ORFNames=CPC735_012060 {ECO:0000313|EMBL:EER29888.1};
OS Coccidioides posadasii (strain C735) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=222929 {ECO:0000313|EMBL:EER29888.1, ECO:0000313|Proteomes:UP000009084};
RN [1] {ECO:0000313|EMBL:EER29888.1, ECO:0000313|Proteomes:UP000009084}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C735 {ECO:0000313|Proteomes:UP000009084};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EER29888.1}.
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DR EMBL; ACFW01000001; EER29888.1; -; Genomic_DNA.
DR RefSeq; XP_003072033.1; XM_003071987.1.
DR AlphaFoldDB; C5NZJ5; -.
DR GeneID; 9697528; -.
DR KEGG; cpw:CPC735_012060; -.
DR VEuPathDB; FungiDB:CPC735_012060; -.
DR HOGENOM; CLU_021479_0_0_1; -.
DR OrthoDB; 2727909at2759; -.
DR Proteomes; UP000009084; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR013752; KPA_reductase.
DR InterPro; IPR013332; KPR_N.
DR PANTHER; PTHR21708; PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE; 1.
DR PANTHER; PTHR21708:SF25; PROTEIN PAM1-RELATED; 1.
DR Pfam; PF02558; ApbA; 1.
DR Pfam; PF08546; ApbA_C; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
PE 4: Predicted;
FT DOMAIN 14..167
FT /note="Ketopantoate reductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02558"
FT DOMAIN 202..325
FT /note="Ketopantoate reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08546"
FT REGION 330..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 586..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..399
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..485
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..528
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 680..750
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 750 AA; 81785 MW; 11D7E450BCBC8B62 CRC64;
MGPMSPSTPR LRVLSVGGNA ISAFLSWRLQ ATNACDVTLV WKQNYEHVAQ YGISFKSKVY
GNERFKPRHV IRHTDEAPSR EQSYDYVILC VKALPDLYDL GEIIHSVVTP EHTCIIVNTT
STLGIESELE HRFPTNVVLS LVSGVDIAQT GPSEFDHTAS SDVWVGPAIK TATIPSTIQT
DMATALSITL GTGQVNCKVS KNIRQEQFER MIGPIAFHPA SVLFETPNYA QLMKKVGVRQ
LVSGVIDELI ALAKALGCSF PEDFRETTIS NMVSQPESPT TMYQDFMARR PMEVETYLGS
PVKLSIDTDV KIPRIETVYA MLHHLNSVNQ ARGNEPTSPV VTHPPRMSSA SRPGVNNVRN
GGRNYSSPQS VPPPRRGGPS MGNHRPPNGL PPPRGAPPQR DAPMEDHGLE EFSHVVNYEA
AAGDIHPGGH MNSLTNGGSS HADLALRERE LRIRQRELQL REQELNMRRG PPSRRMSTTR
DTLDDGDDGD YFDAPPPMPQ IDPDNFDMMS VTSRKNRKVP SNNAGQFRKN PEMAAGRPPS
AFSRAFGMGR NRTSARIVEE FPGMHDSLLD NPMIGYSSNR YGSVDRREMQ AESRANSLTA
SRINDLSQGV GHGPYPPPSR RTSQSPGQGF RPNGRGMGRT STGIDGFNGQ PNGMGHPNRR
SPPGIMRAPV PRHPGQPNGV MPQQVEQQVG VSNSNPAKRH TNVRSLTGSA SASAGSGDSG
ASANIDSETS AHSSQSSLPP YQMLQKPGNK
//
