ID C5Z6E1_SORBI Unreviewed; 1050 AA.
AC C5Z6E1;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Transcription elongation factor SPT5 {ECO:0000256|PIRNR:PIRNR036945};
GN ORFNames=SORBI_3010G078900 {ECO:0000313|EMBL:EER88041.2};
OS Sorghum bicolor (Sorghum) (Sorghum vulgare).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum.
OX NCBI_TaxID=4558 {ECO:0000313|EMBL:EER88041.2, ECO:0000313|Proteomes:UP000000768};
RN [1] {ECO:0000313|EMBL:EER88041.2, ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=19189423; DOI=10.1038/nature07723;
RA Paterson A.H., Bowers J.E., Bruggmann R., Dubchak I., Grimwood J.,
RA Gundlach H., Haberer G., Hellsten U., Mitros T., Poliakov A., Schmutz J.,
RA Spannagl M., Tang H., Wang X., Wicker T., Bharti A.K., Chapman J.,
RA Feltus F.A., Gowik U., Grigoriev I.V., Lyons E., Maher C.A., Martis M.,
RA Narechania A., Otillar R.P., Penning B.W., Salamov A.A., Wang Y., Zhang L.,
RA Carpita N.C., Freeling M., Gingle A.R., Hash C.T., Keller B., Klein P.,
RA Kresovich S., McCann M.C., Ming R., Peterson D.G., Mehboob-ur-Rahman,
RA Ware D., Westhoff P., Mayer K.F., Messing J., Rokhsar D.S.;
RT "The Sorghum bicolor genome and the diversification of grasses.";
RL Nature 457:551-556(2009).
RN [2] {ECO:0000313|Proteomes:UP000000768}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. BTx623 {ECO:0000313|Proteomes:UP000000768};
RX PubMed=29161754; DOI=10.1111/tpj.13781;
RA McCormick R.F., Truong S.K., Sreedasyam A., Jenkins J., Shu S., Sims D.,
RA Kennedy M., Amirebrahimi M., Weers B.D., McKinley B., Mattison A.,
RA Morishige D.T., Grimwood J., Schmutz J., Mullet J.E.;
RT "The Sorghum bicolor reference genome: improved assembly, gene annotations,
RT a transcriptome atlas, and signatures of genome organization.";
RL Plant J. 93:338-354(2018).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR036945}.
CC -!- SIMILARITY: Belongs to the SPT5 family. {ECO:0000256|ARBA:ARBA00006956,
CC ECO:0000256|PIRNR:PIRNR036945}.
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DR EMBL; CM000769; EER88041.2; -; Genomic_DNA.
DR AlphaFoldDB; C5Z6E1; -.
DR STRING; 4558.C5Z6E1; -.
DR MEROPS; A01.040; -.
DR EnsemblPlants; EER88041; EER88041; SORBI_3010G078900.
DR Gramene; EER88041; EER88041; SORBI_3010G078900.
DR eggNOG; KOG1999; Eukaryota.
DR HOGENOM; CLU_005738_1_0_1; -.
DR InParanoid; C5Z6E1; -.
DR OMA; PYPVGYM; -.
DR OrthoDB; 24955at2759; -.
DR Proteomes; UP000000768; Chromosome 10.
DR GO; GO:0032044; C:DSIF complex; IBA:GO_Central.
DR GO; GO:0005840; C:ribosome; IEA:InterPro.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0032784; P:regulation of DNA-templated transcription elongation; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0140673; P:transcription elongation-coupled chromatin remodeling; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd06081; KOW_Spt5_1; 1.
DR CDD; cd06082; KOW_Spt5_2; 1.
DR CDD; cd06083; KOW_Spt5_3; 1.
DR CDD; cd06084; KOW_Spt5_4; 1.
DR CDD; cd06085; KOW_Spt5_5; 1.
DR CDD; cd06086; KOW_Spt5_6; 1.
DR CDD; cd09888; NGN_Euk; 1.
DR Gene3D; 2.30.30.30; -; 4.
DR Gene3D; 3.30.70.940; NusG, N-terminal domain; 1.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041973; KOW_Spt5_1.
DR InterPro; IPR041975; KOW_Spt5_2.
DR InterPro; IPR041976; KOW_Spt5_3.
DR InterPro; IPR041977; KOW_Spt5_4.
DR InterPro; IPR041978; KOW_Spt5_5.
DR InterPro; IPR041980; KOW_Spt5_6.
DR InterPro; IPR005100; NGN-domain.
DR InterPro; IPR006645; NGN-like_dom.
DR InterPro; IPR036735; NGN_dom_sf.
DR InterPro; IPR039385; NGN_Euk.
DR InterPro; IPR014722; Rib_uL2_dom2.
DR InterPro; IPR005825; Ribosomal_uL24_CS.
DR InterPro; IPR039659; SPT5.
DR InterPro; IPR022581; Spt5_N.
DR InterPro; IPR017071; TF_Spt5_eukaryote.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR11125; SUPPRESSOR OF TY 5; 1.
DR PANTHER; PTHR11125:SF7; TRANSCRIPTION ELONGATION FACTOR SPT5; 1.
DR Pfam; PF03439; Spt5-NGN; 1.
DR Pfam; PF11942; Spt5_N; 1.
DR PIRSF; PIRSF036945; Spt5; 1.
DR SMART; SM00739; KOW; 6.
DR SMART; SM00738; NGN; 1.
DR SUPFAM; SSF50104; Translation proteins SH3-like domain; 1.
DR PROSITE; PS01108; RIBOSOMAL_L24; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR036945};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000768};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR036945}.
FT DOMAIN 193..279
FT /note="NusG-like N-terminal"
FT /evidence="ECO:0000259|SMART:SM00738"
FT DOMAIN 284..311
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 436..463
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 488..515
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 612..639
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 723..750
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT DOMAIN 998..1025
FT /note="KOW"
FT /evidence="ECO:0000259|SMART:SM00739"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 775..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..37
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..85
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..131
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1050 AA; 115651 MW; 3F2CFBEBF6F749EC CRC64;
MARRGHDDDD EIEEEEDEEE AYDLDEEEEE DEEDDYEEEA RRGKASRSGG AGGGKGGGGG
RKRSREDNFI DDSAIEDDDE EDDDDDGGGR PRKKGGGGVR GFFDEEAQVD EDEEEEDEGE
GEDDFINDAG ADLPDEDVVR GSRRHSIPMR DEEEDIDEIE RQVRERYARS THIEYGEEAA
EVEQQALLPS VKDPKLWMVK CAIGHERETA ICLMQKYIDR GDLQIKSVVA LDHLKNYIYV
EAEKEAHVKE ACKGLRNIYA SAKITLVPIK EMADVLSVES KSVDLSRDSW VRMKLGIYKG
DLAKVVDVDN VRQRVDVKLI PRIDLQALAS KLEGREAVKK KAFVPPPRFF NIDEAREMHI
RVERRRDKES GEYFEWVDNL KFKDGFLYKS VSTKSIHTNN IQPTFDELEK FKKPGEDMNG
DMASLSTLFA NRKKGHFMKG DAVIVVKGDL KNLEGWVEKV EDETVHIRPK ISDLPKTLAF
NEKELCKYFK PGDHVKVISG VQEGATGMVV KVEGHVLIIL SDTTKEHIRV FADHVVESSE
ITTGITRIGD YELHDLVLLD NLSFGVIIRV EAEAFQVLKG VPDRPEVVLV KLREIKSKID
RRSSAKDRSN NIISAKDVVR VIEGACKGKQ GPVEHIHKGI LFIYDRHHLE HAGFICAKAQ
SCLLVGGSAG GRRGNGMDTA DARLGALRSS ASILQSPGRL PPRGPNMNYG GRFGGGRGGR
GHDALVGKCI KIKSGPYKGY RGRVKEVTGA LVRVELDSLM KIVTVKRDDI ADTPTVATPF
REPRYSLGGE TPMHPSRTPH HAYQTPMRDP GATPIHDGMR TPMRSRAWAP MSPPRDNWED
GNPATWGSSP AYQPGTPQAR PYEAPTPGSG WANTPGVSFN DAPTPRDNYA NAPSPYVPST
PVGQPMTPNS AAYLPGTPGG QPMTPGTVGL DAMSPILGGE GDGTWLLPDV MVNVLRGGDD
GPGVVREVLG DGSCRVALGS SGNGDMVTVL PNEVEVIRPK KSDKIKILNG NFRGYTGKLI
GIDGSDGIVR LDDTYEVKIL DMVILAKLAT
//
