ID   C6H1G9_AJECH            Unreviewed;       458 AA.
AC   C6H1G9;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Ribonuclease H2 subunit B {ECO:0000256|ARBA:ARBA00019062};
DE   AltName: Full=Ribonuclease HI subunit B {ECO:0000256|ARBA:ARBA00033464};
GN   ORFNames=HCDG_00551 {ECO:0000313|EMBL:EER44972.1};
OS   Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=544712 {ECO:0000313|EMBL:EER44972.1, ECO:0000313|Proteomes:UP000002624};
RN   [1] {ECO:0000313|Proteomes:UP000002624}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA   Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA   Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA   Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain H143.";
RL   Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non catalytic subunit of RNase H2, an endonuclease that
CC       specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA
CC       replication, possibly by mediating the removal of lagging-strand
CC       Okazaki fragment RNA primers during DNA replication. Mediates the
CC       excision of single ribonucleotides from DNA:RNA duplexes.
CC       {ECO:0000256|ARBA:ARBA00024778}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; GG692419; EER44972.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6H1G9; -.
DR   STRING; 544712.C6H1G9; -.
DR   VEuPathDB; FungiDB:HCDG_00551; -.
DR   eggNOG; ENOG502SCDS; Eukaryota.
DR   HOGENOM; CLU_057573_0_0_1; -.
DR   OMA; YYFCPKL; -.
DR   Proteomes; UP000002624; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032299; C:ribonuclease H2 complex; IEA:InterPro.
DR   CDD; cd09270; RNase_H2-B; 1.
DR   Gene3D; 1.10.20.120; -; 1.
DR   InterPro; IPR040456; RNase_H2_suB.
DR   InterPro; IPR019024; RNase_H2_suB_wHTH.
DR   InterPro; IPR041195; Rnh202_N.
DR   PANTHER; PTHR13383; RIBONUCLEASE H2 SUBUNIT B; 1.
DR   PANTHER; PTHR13383:SF11; RIBONUCLEASE H2 SUBUNIT B; 1.
DR   Pfam; PF09468; RNase_H2-Ydr279; 1.
DR   Pfam; PF17745; Ydr279_N; 1.
PE   4: Predicted;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT   DOMAIN          32..146
FT                   /note="Rnh202 triple barrel"
FT                   /evidence="ECO:0000259|Pfam:PF17745"
FT   DOMAIN          149..359
FT                   /note="Ribonuclease H2 subunit B wHTH"
FT                   /evidence="ECO:0000259|Pfam:PF09468"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..332
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          394..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        261..327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        399..443
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   458 AA;  51078 MW;  59254682CA45716C CRC64;
     MRTRSLPSRS STNTETCKTA LPEPSKPLKA LILPCDATEE ARFILLENPR SGALCRYYFC
     PKLGLYEFTA ISSTSPRSTL FTTTKSATSL VADKQEHVVR NNSSNMVVGD VSTENTEIIP
     QMVENRIPTK ATIAKQSQLF VATPVDILFF LLPILAPARG NSTSRKRFQP LDDMLDSQDT
     ASKSLKHILS IQFREKVEAR MTVICDTVEA GETMYRLNED KLLRELIFKA ERMAAGGLPQ
     SLEERFIQRA LELPVLSVKR DDLPTTSTSP NPFDATDDTN NPVETSQQKS ELQSSSSTTP
     TATPSASFTA SDVSTPNTAT TPPTKDSPPN CDVRHLLRVR TAISFLASSY LPKHLSSRVE
     TLLNNPETSP KDFSPLTQHL KLVAEMRAKA VASRSMGAFS HKRRVEDDEE VERKAEKKRK
     KEEEERKKKM GESRAMRDLK KVNVSGMKKL SAFFQKKT
//