ID C6HK46_AJECH Unreviewed; 4664 AA.
AC C6HK46;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=HCDG_06577 {ECO:0000313|EMBL:EER39472.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER39472.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG692429; EER39472.1; -; Genomic_DNA.
DR STRING; 544712.C6HK46; -.
DR VEuPathDB; FungiDB:HCDG_06577; -.
DR eggNOG; KOG1808; Eukaryota.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OMA; ILEQWHR; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 9.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 3.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624}.
FT DOMAIN 4501..4664
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 3872..3900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3915..4404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3915..3941
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3942..3974
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3975..4037
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4038..4052
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4053..4069
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4077..4124
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4125..4142
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4143..4178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4199..4218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4237..4254
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4261..4276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4309..4329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4365..4380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4664 AA; 522822 MW; 7F0C7E810EA52FEF CRC64;
MAQFSSDGVL LPHPQILKQL PPELVEILRT GSSIPETFLD TLSIAALQPN YTNKLFTLYE
PIFVDLAARW ICLDSHEYSV QVTTAFARIL PFAPYLRPFV NAVSQRLKSS ALPSSSESNQ
FELLQMEDRT LHAFLVALFR LLSFDLDSFS PMTPVSQLQS LLSHHNPIIR YLAIRCFCLY
MRAADASLEQ MISKYHDETA INGSWEGRTI DYRLLSIWEE KRWAGLKEEL ENARISRVDS
VAETWTKEFR NSFTSHTAEI GGVLLPTIHP KNNMGASCLV ETPTVRRNLR SFGNSLLSMD
PLLLVGLAGS GKTSLVHEAA YRMGHSSSMI TLHLNEQTDS KSLLGLYSTS PQAGSFSWQP
GVLTKAARED IILTTFDRIT SLFNGTLSRK FMTGRLPNLR DLVKLCYRIE RRLRNLGCET
GYEAVPEGTH DEIFMDTVDC FAACFPKGLL QSTVAEVIAE GMQISPQRMN FCLSEQTPKY
LDSPNSVTIG RECFQKRKPL GLRKSSSSTA AHSTFAPTRA SLRVMERIVS SLQLSEPVLL
VGETGIGKTA VIQQLASLLH QRLTVVNLSQ QSESTDLLGG FKPVNVRSIA VPLVDEFNSL
FESTFSAKKN QKFLASVAKC VTTGNWRRLV NILKEAIKMA SGIFEPLNKS KSELTDVVSE
QPSKKRKLDD TKYTILRGKW ATFSRELKEF EVQVSEGDSK FAFAFVQGKI VKALRNGEWV
LLDEINLASP DTLESIASLL HYGGDGTPSV LLSEAGEVER IYGDSNFRIF GAMNPATDAG
KRDLAPGLRS RFTEIYVNSP DTEIDDLITL IGAYLGSLTI ADEKSTISLA RLYLDTKKLN
VDNKLTDGAG QKPHFSIRTL VRSLIYVRNQ AHIYGLRRAM YEGFSMSFLT LLSKASELQI
IRLLDQHIFG SLKNSRSMLS QTPKPPNDGA TYVQFKHYWM RQGEFPLESQ PHYIITPFIE
RNLMNLVRAS STRLFPILLQ GPTSSGKTSM VEYLAKISGN RFVRINNHEH TDLQEYLGSY
VSGEDGSLKY QEGILVEALR NGYWIVLDEL NLAPTDVLEA LNRLLDDNRE LFLPESQEVI
RPNPNFMLFA TQNPAGLYGG RKVLSRAFRN RFLELHFDDI PEDELEYILK ERSQIPPSFC
ARIVSVYRKL SLLRQSSRLF EQRNSFATLR DLFRWAQRRA DDREQLAVNG FMLLAERVRN
PQERAAVKEV IEEVMRVKLD QTAIYSSRCL DARLQQLSAT APTSIIWTQA MRRVFILVSQ
AIEHNEPVLL VGETGCGKTQ ICQAIAEIYG KQLFTINAHV NLETGDIVGA QRPLRNRSTI
EAQLLADLSS VLKSIDAYDE SSDNSIDKLT RVFSELNSQA LDMCEPNLLN RIRENMTRAK
ALFEWSNGSL ITAMESGQHF LLDEISLADD SVLERLNSVL EPHRSLLLAE KGPINLIVAK
DGFQFLATMN PGGDYGKREL SAALRNRLTE IWVPQLSEAE DILPILSSKL VSPISNAPSA
MLAFARWFKE TFQSTSSTSI SIRDLLAWVG FVNQCKDLDQ AAAVVHGAAL VYIDTLGANP
SAMFVSCPAN LKHDRLKCLE RLGEIFGFDA VSIYYQATTI SMEDNNMRIG PFVLEMSAHS
EHDPTFSLEA PTTVANSLRI ARGLQLTKPI LLEGSPGVGK TTLVAALAQC LGKPLTRINL
SDQTDLTDLF GSDVPVEGGD MGNFAWSDAP FLRAMQTGGW VLLDEMNLAS QSVLEGLNSC
LDHRQQVYVA ELDQTFKRHP DFVLFAAQNP HHQGGGRKGL PASFVNRFTV VYADSFSDDD
LKMICKQLSP LAPKREIQQL VEFVSSLNIK ITNERLLGTT GGPWEINLRD ISRWLRLLES
TPIRVSPSQF LDVVISQRFR THGDRSLVLS LYEDVFRSTP VVKSYFHNLS VSQYQVGLSV
LQRDPLVQNF NDPQMKILTG DLAIMESLAL CIEQGWPSIL VGTSGCGKTT ILRKLAALSG
CKLVELALNA DTDTMDLVGG FEQVDNDRHL LSFMDELSQL LQIQVVSTYT ATEQTGMDSE
LVQLYQDVKS GSSNLETISE ALHRISLKGL HPSFTEFYQR SKTLLKSSFV NETIGFEWTE
GIFVQSIQKG DWVVLDNANL CNPSVLDRLN SLMEPNGYLV INEQRTGDGT AKVVKPHPNF
RLFLTMDPRH GELSRAMRNR AIEICLQPGV TGGTPTTQGI FYTSESSIYR IRCGQGLSHQ
RLDSELEQNE LEVFLDHLAP HDFRRLQQSS ISIDIWVANT HLSTVVYQTF DRYNAFLSRD
TLSSLKDFLC DGSWNEHKFS SFRYGIETKQ PLHPLINEPR AVACINPESQ VLLEKLAKLQ
EIQFDVWHFH QVFCQVRDSV SNKKPSEMSR LERSVASDRI PALMKESTQP VALYLSSCIQ
TLSETIQKVN YEVLRSVDVC AMASSILELC WDIFGVVQTN NFDEGVFQTY LQIGQSLCSR
FKDIKLDLVR VLSESLDMFR INWGLTTGQS MQRIWDQWRP ATSTDPAHLK SMVDLQHIAA
RFDLITLKTN LPFSQLGQLR HSLVQAQISM LQGADGVGLI QDLQHVIDDL EARVLDSGPV
SPPYFSLEFE ALSQYRDFID ISKSATETIN YGLSDVLQLL AGRPSCPHDM STLGNSVPEL
LSRLSRFAGF QNVSSKPLAL RGTFSLSLIA KLSSLGIVPV KGMNILNSEL DFIANGLCSS
TDQIARDQLD TLRKQLARLL QELLCCHGDL IDPVSLGSAE SYLDTLVRDS DLSGLVNTQI
PPLKLRDNSD KLHYFNEFAS RSFNKIVSSL VGICGKTGTT NHLQLGAACI HLAMACLRFF
VPNRPFDPSL GLAVQRHRYT QRAQEKNKKL NALKAYELSF SGQESSLRIR IAQEELRLLG
DIPPSPPVIR PQPSQIGELQ GEFSNLLNSV VNLNPDGILR SLQDSANPDL ANTTKQQGEL
LQKNIKQICL RLTTNYKAYE DVVIPVIRFL EILHLGVDLV QCSDLHSHLE QGFIHAMSQI
TPLMSSRRVS LPDLQHRPSR LSNSEKVDIG LQRLSILWVF QNTDPETLST AANRQLLRDT
LEDFSGIWKQ QLEDDQNKHY QKSNLYRYRG SFEDDQEVEA AEVSQLFPTF DGTIGDDLEI
GTLAQFDVKT ISLRLSHILN NLFSDLDKES TVKRLLLDST KLLGINMAKG STDIPTMDPK
SHLLGAILFL DDVKSIKQPT PYNFYSSPNL VEVKKLADLV ETISVRFKEL QNSWPEHATI
ADVIRCCSEI FQFNHQEPLA KFITKAEKLH SFIYEWQAVA SKNFSVTQCY DNITALLISW
RRIELSTWSQ LLDIEDEKCS EDASAWWFVA YDVIIAAPLQ LVQDGQPLIE HSVELITTLE
KFICSTPMGQ YKSRLQLIEK FKMLLTLYAL DFPALDQLSA GIDNLLHHYF PFVSVFEKSL
GDGRRTLERD IQQTIQLASW KDTNINALRE SARRSHNKLF KVVRKYRSLL SQSSESLLSN
GLSGLPDKAE SFSDNRVTLP NPVSPIAHRV CHENIHSWSQ KPRRFTDPDG AVRSMQRVYE
NSLKGLQAHQ ELDAFTRDII DTISEFKSQT PKALTEDNKH DVQHLKGQKR RFYAEKLKDL
RFMGIRSNVG TDILESQRSV ASVLSSTRPL TISAGLSHVK SADSYFHKFL DLVPRVRISS
VEFSEDLSNV EASRSAGFIE GLLHWALKQR ETLSLRLENL SAVELTLQQM RNILPWTELG
VTASTRETND QINISLEEFD SSLFTVMDKI FVVMQKISSS LSTAPPSNDI PAWLVKTEQV
ISKACAELHM ADIADDIRCV LARIRHVSEK DSNSLAVVGA AISVIMPIAE QYQSICTDIL
HRYSALHRET CKMSYLLAKS FNQIASEGFC APPENTGEHG KSDKLENGTG LGDGEGAEDI
SKDVQDDEDL ADLAQEKQQM DGDKEDKDTG VDAVNMDQED LEADRSDFDD EMENEDGSCS
DKEDEDDMDL DEETGSVDRL DASAVDEKMW DGTNDQDQKD TENEQGKGDA ESEDKTAASA
NKNEKINESK NGDESENEGS EPPDDEGEAV GREDMDTTDP HAKEEPILDL PEDMELDGQD
DKDKQDSDFD NDLGDLSDDN RSNWEGEPNA PEESNDHPDL DPQEQAENET EPANEVEEEN
LNGQEDVECH QEESETGTEE KERDELLESE RTDNQADAED IAPSEEVSVS QGVDQDQNQE
HGDSGKATQE HGSKDQADEQ NLQEGSADQG EDGKEATNVS GGRDDGKLDD SQTQAFKKLG
DILEQWHRRQ RQIQEASDHQ DTSQNENQDA NMEDADFEHL ADDQDAADTQ ALGQATEEQA
KSLDQSNAVE SDVRPEEGEF LPDATEPENP PAEQSLEDRM DLDQQPGLSE NNTSRSYVAG
DRITENDPTH QDSQTSDSQE MEDMDAHLSS FHVGSETTPL TSPEEARRLW SHYESITNDL
SLALTEQLRL ILAPTLATKL RGDFRTGKRL NIKRVIPYIA SQYKRDKIWM RRSVPSKRSY
QIMLAVDDSK SMLESGSGQL AFETLALITK SLSMLEAGDL CVVSFGDEDH VRVAHEFGKT
FSSEAGVQIF QQFSYKQTGT NVRKLISDSI TLFREAKMKR SRSSGSGDLW QLELIISDGI
CEDHEAIRRL VRQAQEERIM IVFIIVDAVK GELHPRSNTS EFRA
//
