ID C6HLS6_AJECH Unreviewed; 978 AA.
AC C6HLS6;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Anaphase-promoting complex subunit 5 {ECO:0000256|ARBA:ARBA00016066};
DE AltName: Full=Cyclosome subunit 5 {ECO:0000256|ARBA:ARBA00031069};
GN ORFNames=HCDG_07545 {ECO:0000313|EMBL:EER38676.1};
OS Ajellomyces capsulatus (strain H143) (Darling's disease fungus)
OS (Histoplasma capsulatum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX NCBI_TaxID=544712 {ECO:0000313|EMBL:EER38676.1, ECO:0000313|Proteomes:UP000002624};
RN [1] {ECO:0000313|Proteomes:UP000002624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H143 {ECO:0000313|Proteomes:UP000002624};
RA Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D.I., Hepburn T.A., Howarth C., Jen D.,
RA Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S.,
RA Nino-Vega G., San-Blas G., Taylor J.W., Mendoza L., Galagan J.E.,
RA Nusbaum C., Birren B.W.;
RT "The genome sequence of Ajellomyces capsulatus strain H143.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
CC {ECO:0000256|ARBA:ARBA00025025}.
CC -!- SIMILARITY: Belongs to the APC5 family.
CC {ECO:0000256|ARBA:ARBA00007450}.
CC -!- SIMILARITY: Belongs to the SUI1 family.
CC {ECO:0000256|ARBA:ARBA00005422}.
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DR EMBL; GG692431; EER38676.1; -; Genomic_DNA.
DR AlphaFoldDB; C6HLS6; -.
DR STRING; 544712.C6HLS6; -.
DR VEuPathDB; FungiDB:HCDG_07545; -.
DR eggNOG; KOG4322; Eukaryota.
DR HOGENOM; CLU_010478_0_0_1; -.
DR OMA; DANMGMA; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000002624; Unassembled WGS sequence.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd11566; eIF1_SUI1; 1.
DR Gene3D; 3.30.780.10; SUI1-like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR037679; Apc5.
DR InterPro; IPR026000; Apc5_dom.
DR InterPro; IPR001950; SUI1.
DR InterPro; IPR036877; SUI1_dom_sf.
DR InterPro; IPR005874; SUI1_euk.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR01160; SUI1_MOF2; 1.
DR PANTHER; PTHR12830; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR PANTHER; PTHR12830:SF9; ANAPHASE-PROMOTING COMPLEX SUBUNIT 5; 1.
DR Pfam; PF12862; ANAPC5; 1.
DR Pfam; PF01253; SUI1; 1.
DR SUPFAM; SSF55159; eIF1-like; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50296; SUI1; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000002624};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..978
FT /note="Anaphase-promoting complex subunit 5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002966024"
FT DOMAIN 893..963
FT /note="SUI1"
FT /evidence="ECO:0000259|PROSITE:PS50296"
FT REGION 782..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 109485 MW; A840BDB4B586326F CRC64;
MTRYLTPSKI SLLALVSVYA EGVVPNSAII PVLSFLVSHL LPPQPSTQHL TSSNTTTQDS
NHAIPIQDFE AATSSLASSI PGRTVWDLLL KKLWKLGCSD ALDEFFAGIL TMLTKTREDQ
INDRNNGIVP QTGRMMISRT SLLGMFVRRA HLEYTRLQFH DAVALWRGFI KYRLPTYQMW
AKRNPLDSQS AVDVNLVELG LDLTSPLVKV VYGALEEGKD VEVGMSMRDI ERLLDFQVGE
MQGNGCRITG EIKSRLEQMV MSGVSVPSSQ HYIKFLDAWK AGDYPSSFDH LHRYFDYTMQ
SRDRTFYQYA LLNLAILQAD FGCHAEAVAA MQEAISIARE THDMSCLNFC MSWLYHFGKA
FPDEMKDIQN TGMLGSEKEG LAFLQAKARE TEMWGLLGTS LLSEAKLELQ NGESVASAFE
HIVKASFLNV TKDAPNLAGP LLMLQASTYS RIESCNAEGV AHLAWSNCEI FRECYAEQAP
HEDNLRVTCR GSMLGKKLTV RSWPLEEAMA CLWLGLADQL SRDDKLAAEQ LISQLHACAP
PDTELVLTLS LLEVDFLMRK GDYTAALEIV ERNAQSMRQE NFDVATQVKL LVYKARIFDQ
TNQPERGFSL AMRAANIAHR SRYLPGLWES IGVLSVILMA FKEFEAAVEI LESIVPQVHE
CEDAYLTART YSLLADANMG LAGQVQVHSQ GRDKVRQKEH MARAVEFIDC AFGAFSNVED
VQGQCEMMAK KATVMHLSGD LVLANDYAAN PPGASRPKTV FEILIEFDNF APYLALGDNR
RRPKKLTRQA PGAHPAESTL SHTSCPLPLK FLSPAICFPH HLPSPKSSSL LVLAHRSPLF
KTLSFYLNCT LYSFFKSVAT NNEFMSIENL KTFDPFAEAD EDTGDTKQSQ NYIHIRIQQR
NGRKTLTTVQ GLPKKFDQKK ILKVIKKKFA CNGTIVNDSE MGEVIQLQGD QRKDVQEFLV
DKKEGLELDA KTIKVHGF
//
