ID C6KE38_9CLOT Unreviewed; 227 AA.
AC C6KE38;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Lactate dehydrogenase {ECO:0000313|EMBL:ACS75686.1};
DE EC=1.1.1.28 {ECO:0000313|EMBL:ACS75686.1};
DE Flags: Fragment;
GN Name=ldhA {ECO:0000313|EMBL:ACS75686.1};
OS Clostridium sp. IBUN 158B.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=400088 {ECO:0000313|EMBL:ACS75686.1};
RN [1] {ECO:0000313|EMBL:ACS75686.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IBUN 158B {ECO:0000313|EMBL:ACS75686.1};
RA Montoya J., Schiel B., Bernal M., Montoya D., Duerre P.;
RT "Metabolic engineering of the Colombian strain Clostridium sp. IBUN 158B
RT for efficient 1,3-propanediol production from glycerol.";
RL Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00005854}.
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DR EMBL; GQ180218; ACS75686.1; -; Genomic_DNA.
DR AlphaFoldDB; C6KE38; -.
DR GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43026; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR PANTHER; PTHR43026:SF1; 2-HYDROXYACID DEHYDROGENASE HOMOLOG 1-RELATED; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:ACS75686.1}.
FT DOMAIN 11..197
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACS75686.1"
FT NON_TER 227
FT /evidence="ECO:0000313|EMBL:ACS75686.1"
SQ SEQUENCE 227 AA; 25609 MW; 792355B014BE676C CRC64;
YSPSSVADYA IMMILMSVRK MKLILDRSTV QDFSLNMVQG KELKNLTVGV LGTGRIGETV
IKHLSGFGCN IIAHDVYEKD TVKKYAEYKN LDYLLKNSDI LTFHMPATED NYHIINKKTI
SEMRDNVFII NTSRGSLINT EDLIEGLEKG KIAGAALDVI ENESGLYYND LKGKILQNRH
LAILKSFPNV IVTPHTAFYT DQAVSDMVEN SIKSILLFDQ NKDNPWQ
//
