ID   C6KRH8_CAEEL            Unreviewed;       758 AA.
AC   C6KRH8;
DT   01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=GTPase-activating protein rrc-1 {ECO:0000313|EMBL:CAZ65502.1};
GN   Name=rrc-1 {ECO:0000313|EMBL:CAZ65502.1,
GN   ECO:0000313|WormBase:F47A4.3c};
GN   ORFNames=CELE_F47A4.3 {ECO:0000313|EMBL:CAZ65502.1}, F47A4.3
GN   {ECO:0000313|WormBase:F47A4.3c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CAZ65502.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CAZ65502.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CAZ65502.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284606; CAZ65502.1; -; Genomic_DNA.
DR   RefSeq; NP_001257090.1; NM_001270161.1.
DR   AlphaFoldDB; C6KRH8; -.
DR   SMR; C6KRH8; -.
DR   PeptideAtlas; C6KRH8; -.
DR   EnsemblMetazoa; F47A4.3c.1; F47A4.3c.1; WBGene00009800.
DR   GeneID; 181195; -.
DR   KEGG; cel:CELE_F47A4.3; -.
DR   AGR; WB:WBGene00009800; -.
DR   WormBase; F47A4.3c; CE43859; WBGene00009800; rrc-1.
DR   HOGENOM; CLU_021271_0_0_1; -.
DR   OrthoDB; 2875845at2759; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00009800; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR   ExpressionAtlas; C6KRH8; baseline and differential.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR15729:SF10; GTPASE-ACTIVATING PROTEIN CDGAPR; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:C6KRH8,
KW   ECO:0007829|PeptideAtlas:C6KRH8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          164..243
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          280..473
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          590..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..624
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   758 AA;  86933 MW;  E5D2A5487FE54453 CRC64;
     MEGIEESFAP LSPKSPFARR NGRSLRIQRL VDCQHFHYSS VELGPVRVAI IAINADENAT
     ERIKMRVESE SNSWLVERSR EDWAVFDRQL HRCVFERRHS RLDELFPLIH LETAKFEEVL
     VKYTERLSEL TGSIITCYPV LKFLEIDSRG GHFEPAEETS INVPAIAAAV VTKDFEPTES
     SQLRLRVGDI VSITEMSTAS PSEQTFWKAK LTISNQKIVD PQNARLGFEI GYFPRDCVML
     IDDKRLPNPL NNEQKASTRN ARRYMTTMFR NRRREPIFGL ELTDLYMRTG KKVPVIVEKC
     CASIEDQGIV TGIYRQCGIQ SNIQRLRAKF DSGAEPDLHE FGQRDIYSVS SLLKQYFRQL
     PNPLFTYQAY PKLIEAFEKE DSLSEKVESL RFSLETMPEA HYRTAKFLME HLTRLCKSKS
     LTDMTSKNLA IVWSPNLFRP PPTLNGADTH LLSGLNVHTA ICDFFIENSE SLFVNDIDEE
     QSKCTSVENS FTTISKSATM SDMRSESESK WPRFFRGKSV EGFWKFNRKQ QTSTGELCGS
     PTSEVKWRRS TRSHSTDAAF QSSRTDSFIQ LMHTGMDQIR EGMRIFRARA RSMRPTSRPP
     PSPRTRRARF SNGSSNNVQK LNESDIQHEI PLATTEPSIT PEPKNTVDPH QIMTRTISVN
     DSDDQSFEEN GLREMRERKV MFKAATQEHV ATFHERSSPV EEWSSDSRES LHLEMSRYDN
     VSPSGTITRN QREPITNLSP AAQMLFFESS RASHLFSA
//