ID C6KSR3_PLAF7 Unreviewed; 663 AA.
AC C6KSR3;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Polypyrimidine tract-binding protein, putative {ECO:0000313|EMBL:CAG25235.1};
GN ORFNames=PF3D7_0606500 {ECO:0000313|EMBL:CAG25235.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAG25235.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAG25235.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
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DR EMBL; AL844505; CAG25235.1; -; Genomic_DNA.
DR RefSeq; XP_966055.1; XM_960962.1.
DR AlphaFoldDB; C6KSR3; -.
DR SMR; C6KSR3; -.
DR STRING; 36329.C6KSR3; -.
DR PaxDb; 5833-PFF0320c; -.
DR EnsemblProtists; CAG25235; CAG25235; PF3D7_0606500.
DR GeneID; 3885785; -.
DR KEGG; pfa:PF3D7_0606500; -.
DR VEuPathDB; PlasmoDB:PF3D7_0606500; -.
DR HOGENOM; CLU_414199_0_0_1; -.
DR InParanoid; C6KSR3; -.
DR OMA; CAANSCA; -.
DR OrthoDB; 4825346at2759; -.
DR PhylomeDB; C6KSR3; -.
DR Reactome; R-PFA-72203; Processing of Capped Intron-Containing Pre-mRNA.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0008187; F:poly-pyrimidine tract binding; ISS:GeneDB.
DR GO; GO:0043484; P:regulation of RNA splicing; IBA:GO_Central.
DR GO; GO:0008380; P:RNA splicing; ISS:GeneDB.
DR CDD; cd12422; RRM2_PTBP1_hnRNPL_like; 1.
DR CDD; cd12698; RRM3_PTBPH3; 1.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR034797; PTBPH3_RRM3.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF18; SMOOTH, ISOFORM T; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 465..539
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 583..660
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 266..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 93..129
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 266..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 663 AA; 77219 MW; 7FFC28B335D56165 CRC64;
MNKRTLSDDR NTREKNKVGV KRYLMSSDDI YDNPKLYHEK NNGGSKINMS TFLEINEDGM
LYDNHNNNIM NGHNNDMCDL SNNNNNNNIF NSLNKIDNNN NIKDNEVNKI NNENNNNNIM
NNINNINNNS NNNNNNNNNN GNNCLSTKYY SNDCKKRKGS RYTSSLPFLK KEKNNGNTVL
LLKNVPEKVD EEDIISFMRP FLRNKNPEII FDGQDIIVKL YDDELIESIY TYFNEHPTQI
KGSFVKVKLS HIIDDNKESM EEQNDILNNY NNNNNNYSSS SSNNNNYSFY HTNHNNHPTD
VLDKRNSKSN KAECSKVILV SVINLHYPVD IELIYYLFSK CGTVEKIITF SRNPVLYQAL
VQFDNVETAK EAIKTLHNRN IYDGCNTINI QYSFLKELVI KGNNSSSWDY TISNEKKTKN
FPVLQNSHGV LPTPSRKSVD SELYQLMEKK FKLVDFEKMN PSKTPVLICY NIPKEYTDVN
KLFNLFSIYG FVTRIKILRE KPDAALIQYS NYIFSSLAQE YLQRARISNQ SIEVNFSKIH
DIRVSQRQQN NESHNTKIFS NYDQRYVLSD QGKYIKAACR PTKCLFISNL NENVNEDCVM
NLFNKYGNIN KLQFLPVKEG KRHLSIIVEM NTEDMATKAL MDLHNFYLKD RYIKVSYTKS
RLM
//
