ID C6KT06_PLAF7 Unreviewed; 1371 AA.
AC C6KT06;
DT 01-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 01-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=TRAP-like protein {ECO:0000313|EMBL:CAG25403.1};
GN ORFNames=PF3D7_0616500 {ECO:0000313|EMBL:CAG25403.1};
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329 {ECO:0000313|EMBL:CAG25403.1, ECO:0000313|Proteomes:UP000001450};
RN [1] {ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S., Chan M.S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000313|EMBL:CAG25403.1, ECO:0000313|Proteomes:UP000001450}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C., Harris B., Harris D.,
RA Mungall K., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corto C., Cronin A., Davies R.,
RA Davies P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James D.,
RA Johnson D., Kerhornou A., Knight A., Kontfortov B., Keyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., McLean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M-A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
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DR EMBL; AL844505; CAG25403.1; -; Genomic_DNA.
DR RefSeq; XP_966151.1; XM_961058.1.
DR AlphaFoldDB; C6KT06; -.
DR SMR; C6KT06; -.
DR STRING; 36329.C6KT06; -.
DR PaxDb; 5833-PFF0800w; -.
DR EnsemblProtists; CAG25403; CAG25403; PF3D7_0616500.
DR GeneID; 3885982; -.
DR KEGG; pfa:PF3D7_0616500; -.
DR VEuPathDB; PlasmoDB:PF3D7_0616500; -.
DR HOGENOM; CLU_256320_0_0_1; -.
DR InParanoid; C6KT06; -.
DR OMA; ETNIPCC; -.
DR OrthoDB; 242287at2759; -.
DR PhylomeDB; C6KT06; -.
DR Proteomes; UP000001450; Chromosome 6.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0048870; P:cell motility; TAS:GeneDB.
DR GO; GO:0044409; P:entry into host; TAS:GeneDB.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00090; TSP_1; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00209; TSP1; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50092; TSP1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1371
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002968036"
FT TRANSMEM 1310..1329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 338..527
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 540..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..1019
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..556
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..596
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..963
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 968..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1371 AA; 160119 MW; 050F7687BF20A92E CRC64;
MNAPYPLVCL ALWLLFLLDV RKCEKLISKL TKNGDLDLVL LYDIGFVDDS ENDHMNSLEN
IAELGKNLLV RDNKNINLSY ITYDDINVDL RIESRNNIGV DNENNYDKDN NSSYKFGSDK
NIEEFRNVVL DTKLKSSYKN SAHLKALNYV GLKHFYNSEK ESVKMVVMFM NTDGDYNNNN
NNNMNNISSS YSAELNLVHY LFDRKNIILN IITRVAFKNY CHYIQQIGSN TNELLKCVLK
NSFYNISALT YEIIKYYDDI SINAICHGWS EWSPCSVTCN MGYHFSKRDS LGYIKNSKSG
LYKRKGRSCL EQRNLIIQEC FNTSCDHSLD ICDNIYMDIS ILLDDSSNIT LESWNKYIIP
FVRKFITHFN INNNQINFSL TTYSSHTYNW FNFSNVLSKD KDKLLTYLEF FKFNFGSSTK
NIKQAIQYMN DHVLNTNYRR NDAKKIMLII NSGEIDNKTV TSVPDIIQRL KDTHNVQVYS
ICINNQNVKN CRKLSTHSME KYGSNFAFSL PNASDLRYNV LGIQKSICRN VSGAFRRKLR
SGNKDDEDKK DDEYKEEDEY KEEDEYKEED EYKEEDEYKE EDEYKEEDEY KEEDEDMKKD
EDMKKDEDMK KDEYKKGYKD YKKDQSKNDN KTEERKDEGN ISTSNEHHAS EKTDDEDIIT
QYNEEDRHDN SNDNIIIDDE PVGQDNSIFK NENFFWGRGK HDSKYTSKLS INSLGDINEY
NDDYNNYDYY DDDPTNRNKG FLKKNSIILK SLYNLNEDYV NNNINNDAGS TSSHCRNNNS
GHNDIPHFKN MRKYNSETNI PCSSKSNKST NKKLLNRLYN MLFRKKKKYR IKNMDAHSKK
KVEKFIENIK FSKENNDDNR KIDEQNIEIQ FDTLLDGIFD FLQDYDNSSL NAFNNSTPDD
DFVYFSNTTP CGVSLMDFPI YDMENMEADV GGKRNDGDNN DDDDNNDDGD NNDDGDNNDD
DDNDDKSNNN NNNNNNGDPS SNNNNNNNNN NGDPSSNNNN NNNGDPSSNN NDDGDADEKR
NDYISQYNLV LKDKSHNNNY YMTNEHDERK IKKQENIDIL SKEEDNISSN YNNELQRTKR
SLDFPEIIIK ENYENPKDII HISKKEEANE SNNSKGHINL KNKKEHNNVV DNVNPCNKQN
INEEDNNINN SIKTARIGIF NKNKINCRNK KASKFDKIKR FNDKINKDNH PLITNVENKN
EEIDVLQNNE DKKQKILPII KNENAKETGQ KYENNDVYEE HNKTNINNNV EKLYKDKNSH
HIKNQYDKGN LTENNEVTPI YSKDYDADDE EYEHWHGHQR DNKSTPVYKY AASFTLAAIL
FLGLSLYFIN NRKGNKIVDA KESNDFAVST NVKETSSKEQ NIEIMNDTQW K
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