ID   C6LVM3_GIAIB            Unreviewed;       683 AA.
AC   C6LVM3;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   SubName: Full=Long chain fatty acid CoA ligase 5 {ECO:0000313|EMBL:EES99931.1};
GN   ORFNames=GL50581_2829 {ECO:0000313|EMBL:EES99931.1};
OS   Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=598745 {ECO:0000313|EMBL:EES99931.1, ECO:0000313|Proteomes:UP000002488};
RN   [1] {ECO:0000313|EMBL:EES99931.1, ECO:0000313|Proteomes:UP000002488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX   PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA   Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA   Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT   "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT   is human giardiasis caused by two different species?";
RL   PLoS Pathog. 5:E1000560-E1000560(2009).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EES99931.1}.
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DR   EMBL; ACGJ01002422; EES99931.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6LVM3; -.
DR   EnsemblProtists; EES99931; EES99931; GL50581_2829.
DR   VEuPathDB; GiardiaDB:GL50581_2829; -.
DR   OMA; ARATMAH; -.
DR   OrthoDB; 1650656at2759; -.
DR   Proteomes; UP000002488; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR   PANTHER; PTHR43272:SF3; LONG-CHAIN-FATTY-ACID--COA LIGASE 5; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:EES99931.1}.
FT   DOMAIN          66..464
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   683 AA;  77227 MW;  9BCC440F06F0A30C CRC64;
     MSHLTTYSNP YKSKTGLGDD LVTAPAGEET LYDIWEKYSL LRLDELVYFH SPIRFNAQTQ
     AIERLAYEGI TYRTMRSNIE RFATAFVTKF GLKPGSMVML WACNSPEWII TEQACNRQSM
     VLVPIYDSLS THGMSYCIDA TKPDILVVSR DKIGRLVKVL TQTPVDLSFL KAIILTTDLE
     FERAIPGNQV EELNQLLARS GMANPHLTDL LGYITAAVHV VPPVPPTPNT ISSLIYTSGT
     SSTPKGVIIS HGALTSACYG YLLTPLDYVR NGKGVHYLSY LPMAHIYERV IQATGIIIDG
     KVYFWRGDFK TLLRDMQEVK PDILCGVPKV YTTLYQAIRS KLEASPLTRR WFHYGLKGDS
     MLQRFAKRCL YGLVRHKIGV NFKLMISGGA SLPPKVHLFV QDFFQCNLIQ GYGQTETCAC
     VTVQCESDYS VDNCGVVCPN MELRIDPAEN EVLLRGSSMF SRYYVPGERF YENVHDFPPS
     TDWYRSGDCG LMTEDNKLVL KDRINTNFKL QNGEFVCPET IELMYLQSAL ISAIYIPQTP
     NSNHLYAFVV PSESLLTKMN VANYFSPDQP LSLTGFHDKL ADDMATDSVR TNEQVEALEP
     FSILEGKHIE NHIIGLLKQK IMKDLTKVHS EAGMKPFMYL KDIHLLRHEL TIENGYLTAT
     QKLCRKKLYT QLQPEIEAMV DKE
//