ID   C6LVW9_GIAIB            Unreviewed;       619 AA.
AC   C6LVW9;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Molybdenum cofactor sulfurase {ECO:0000313|EMBL:EES99835.1};
GN   ORFNames=GL50581_2926 {ECO:0000313|EMBL:EES99835.1};
OS   Giardia intestinalis (strain ATCC 50581 / GS clone H7) (Giardia lamblia).
OC   Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX   NCBI_TaxID=598745 {ECO:0000313|EMBL:EES99835.1, ECO:0000313|Proteomes:UP000002488};
RN   [1] {ECO:0000313|EMBL:EES99835.1, ECO:0000313|Proteomes:UP000002488}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50581 / GS clone H7 {ECO:0000313|Proteomes:UP000002488};
RX   PubMed=19696920; DOI=10.1371/journal.ppat.1000560;
RA   Franzen O., Jerlstrom-Hultqvist J., Castro E., Sherwood E., Ankarklev J.,
RA   Reiner D.S., Palm D., Andersson J.O., Andersson B., Svard S.G.;
RT   "Draft genome sequencing of giardia intestinalis assemblage B isolate GS:
RT   is human giardiasis caused by two different species?";
RL   PLoS Pathog. 5:E1000560-E1000560(2009).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EES99835.1}.
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DR   EMBL; ACGJ01002453; EES99835.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6LVW9; -.
DR   EnsemblProtists; EES99835; EES99835; GL50581_2926.
DR   VEuPathDB; GiardiaDB:GL50581_2926; -.
DR   OMA; WEWDRIF; -.
DR   OrthoDB; 448292at2759; -.
DR   Proteomes; UP000002488; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000192; Aminotrans_V_dom.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR14237:SF19; MOLYBDENUM COFACTOR SULFURASE; 1.
DR   PANTHER; PTHR14237; MOLYBDOPTERIN COFACTOR SULFURASE MOSC; 1.
DR   Pfam; PF00266; Aminotran_5; 2.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          130..249
FT                   /note="Aminotransferase class V"
FT                   /evidence="ECO:0000259|Pfam:PF00266"
FT   DOMAIN          351..598
FT                   /note="Aminotransferase class V"
FT                   /evidence="ECO:0000259|Pfam:PF00266"
SQ   SEQUENCE   619 AA;  68896 MW;  79E5D67C923EC291 CRC64;
     MTSVFIFSAR MHDEEGTKYH SVHRQSSRNS SLIIPLLAGV ASGMLFMLLL TLGYKVGLDA
     FIRPANLSNE SAADYGFTNV AAHISERGIA AKPSADAQSW MKKYPAYAYG GSLYAWRHIE
     FPNLGANSTY LDFTGSGLFQ VSQLKESLKF LESALFCNIH SDSACSRNSE KAVDDIRDMI
     LEFFNAPRGT YSVIFTSGAS AGLQLIAHSF PWSNKSHFMY SKHNHNSVLG MRRVALKHGA
     NFGTFPFDLY RMSLEEEFVR LCNTSYLKLA KGSGDASDTG KIHRPTARDI AFHKEVDSVY
     RNKTHHLIAF PAEDNFSGVK YNLDLIHAFQ SGEFAAKFMN TTNMCTSKNS VWHVLLDAAA
     FVPTNPLDLD KYPASFVVVS FYKMFGYPSG VGALLVRNDI NPLLQKTFFG GGAVVLASCE
     SDYCKLKPSY HERFEDGTLN FLHIPSLRYG FNILKTLGME NIQAHVWAVT RRAYEGLTAL
     KHHNGLPLVE VYGEHARNDM AMQGGIVAFN LKDVDGNYLG YYGFSRHAAK HGFMLRVGCN
     CNPGACNTYV GISEEDVIEA SKNKTSCGDE LDMVKGIPLG AIRLSLGYIT TIEDVDRFVD
     FVKHYYTNRR GSYEDLQTK
//