ID   C6SCB8_NEIME            Unreviewed;       550 AA.
AC   C6SCB8;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Sulfatase N-terminal domain-containing protein {ECO:0000259|Pfam:PF00884};
GN   Name=wcbQ {ECO:0000313|EMBL:CBA05845.1};
GN   ORFNames=NME_0934 {ECO:0000313|EMBL:CBA05845.1};
OS   Neisseria meningitidis alpha153.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=663926 {ECO:0000313|EMBL:CBA05845.1};
RN   [1] {ECO:0000313|EMBL:CBA05845.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Alpha153 {ECO:0000313|EMBL:CBA05845.1};
RX   PubMed=18305155; DOI=10.1073/pnas.0800151105;
RA   Schoen C., Blom J., Claus H., Schramm-Glueck A., Brandt P., Mueller T.,
RA   Goesmann A., Joseph B., Konietzny S., Kurzai O., Schmitt C., Friedrich T.,
RA   Linke B., Vogel U., Frosch M.;
RT   "Whole-genome comparison of disease and carriage strains provides insights
RT   into virulence evolution in Neisseria meningitidis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:3473-3478(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AM889137; CBA05845.1; -; Genomic_DNA.
DR   AlphaFoldDB; C6SCB8; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   CDD; cd16015; LTA_synthase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR47371; LIPOTEICHOIC ACID SYNTHASE; 1.
DR   PANTHER; PTHR47371:SF3; PHOSPHOGLYCEROL TRANSFERASE I; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        24..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        51..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        127..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          210..454
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   550 AA;  62304 MW;  C592277AC591831E CRC64;
     MVAYVFLFLF VTAALVLIIR SHYRWTYFFA SALFVFLAGG MLMLTAQWQR ALNFASVWFV
     VLILFHRLKI HYYKQPLLIS DFLLIADWRN WETLFHYKEA VIGMAGLLAL AAYAVFGWSG
     ADALGLPWRW AGTVLFAAAF VSMRHFSKHP GAVKTWLDSL PDDGRDVFLN LPMSCRAVFF
     QVPVFEGDGE AFAKQMPSET QPYGMSDEKP DIVVTLMEST LDPHCFDFAA AKIPDLKMFG
     RQEDTVFSSP LRVHTFGGAT WKSEFAFLAG VPSTDFGALA SGVFYSVVPH LQTGFVRNLR
     EHGYFCVALS PFTKGNYNAK AAYDHFGFNL MFQPQDLGYP APMGKNLWHI SSEEMMQYAR
     MILEKRHPDL ENVRQPMFVY VLTMKEHGPY RTDTDNVFDL DAPDLNAKTV SALNDYIGRI
     ADLDKAVESF DRYLHERGKP FVFGYFGDHQ VPFEGVSVRK KWDYAQPDYV TQFAVRSNIA
     GGFVQRQDFL DLAFAGGVLM EAAGLEAKDG FMRANMAMRG LCGGGLEDCP NRKLVGDYRN
     YLYDVLKIVR
//