ID C6X052_FLAB3 Unreviewed; 1064 AA.
AC C6X052;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=FIC_00264 {ECO:0000313|EMBL:ACU06737.1};
OS Flavobacteriaceae bacterium (strain 3519-10).
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae.
OX NCBI_TaxID=531844 {ECO:0000313|EMBL:ACU06737.1, ECO:0000313|Proteomes:UP000001512};
RN [1] {ECO:0000313|EMBL:ACU06737.1, ECO:0000313|Proteomes:UP000001512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3519-10 {ECO:0000313|EMBL:ACU06737.1,
RC ECO:0000313|Proteomes:UP000001512};
RX PubMed=18622572; DOI=10.1007/s00792-008-0178-2;
RA Raymond J.A., Christner B.C., Schuster S.C.;
RT "A bacterial ice-binding protein from the Vostok ice core.";
RL Extremophiles 12:713-717(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CP001673; ACU06737.1; -; Genomic_DNA.
DR AlphaFoldDB; C6X052; -.
DR STRING; 531844.FIC_00264; -.
DR KEGG; fba:FIC_00264; -.
DR eggNOG; COG1074; Bacteria.
DR HOGENOM; CLU_010638_0_0_10; -.
DR Proteomes; UP000001512; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 1.10.3170.10; Recbcd, chain B, domain 2; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF64; ATP-DEPENDENT DNA HELICASE REP; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001512}.
FT DOMAIN 1..485
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 496..761
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 21..28
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1064 AA; 122896 MW; B1CF26009928D54C CRC64;
MLLLKSIYNS MVQKNYRVIN ASAGSGKTYA LVQNLLVICL KHPSQPDKIR NILALTFTNK
AANEMKQRII KWLREFSSAE YANNQDLKNI QQKMKVQGIE LSLETLHKRS RKILDYVLHN
YSTLNIGTID KFNSRLVRSF SYELGLAQNF NLEINAEPYL VEAVEKMLAD IGAENDVSDA
FMDFVNYSLD NNERVNLNKT LYDSAKEFVQ DKHYFRLSQN KEFDWKVYGE AKQRLRDNIK
SLKEDSLKIT ETCINLLNEK NLEIADFSGG SKNSIAKFII EAARFYKKER ADFPFPSNEE
TALTNFQSGA SSKSKNRQSE ILEILDFLIE SRSKIIKNYI ETQREEKILH ALLPLKVNKD
IQDKLAEIEE KNDVVLLSKF NILIHENLRE EPSSFIYEKV GTQFSHYFFD EFQDTSFLQW
QNFIPLRDHA VSSDEMSFTL VGDPKQSIYR FRGGDSQLML DIINKQEKSL VLADLENLGD
NWRSAKNIVD FNNQLYQFLS AHTQEAHCDI FGKGSQQTPK SESSGRVRIN LIENSTKAIY
YEDVAEKMCE DLQACVDNGF RFADITILCR GNFDIFSFSN LLGNLKINYN GKEEFIKTIS
ESGLTLNLSS TLLALTEFLR WEQNPKNFQF PVKMLYYLNI LGRITIEDFS ADMMEMLAFK
TKPEIQDFIE NRYGIRLRNE TLLQLNLYNF VEHFLQEFSV AGKETDFLFN YLEMLYAFSQ
NAGANLKDFL RFWDEEAQEA TIQASDNLDA VKLMTIHKAK GLEFPVVFLP MANSHKDGKF
SNWLDIKDHA GLAAVNVPSF GKELEVYDED MAKFNQENNY QNKIDRFCLQ YVATTRAAEQ
IFLYIEKPNK TTNNLEIYEF LEPNIPLNEH LEPLSSFDLY EVSPEILKKK ESDKAETAVT
QAVRFKNEKV PNPAAIQIAT PSKSYQNRVE KVRTGIFTHE ILAKINSKDD VEKTLENYLL
DGIITQTEKQ YISERLLTII NDGRYAQYFA PNQRVINEKD IMISAGGESK IYRPDRLIDT
GDGYIIIDFK TGGVKEKHQQ QVDEYQSVLE KLGMKVRETA IVYV
//
