ID   C6X7W3_METGS            Unreviewed;      1188 AA.
AC   C6X7W3;
DT   22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 1.
DT   24-JAN-2024, entry version 56.
DE   SubName: Full=ATP-dependent exoDNAse (Exonuclease V) alpha subunit-helicase superfamily I member-like protein {ECO:0000313|EMBL:ACT51290.1};
GN   OrderedLocusNames=Msip34_2048 {ECO:0000313|EMBL:ACT51290.1};
OS   Methylovorus glucosotrophus (strain SIP3-4).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Methylovorus.
OX   NCBI_TaxID=582744 {ECO:0000313|EMBL:ACT51290.1, ECO:0000313|Proteomes:UP000002743};
RN   [1] {ECO:0000313|Proteomes:UP000002743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIP3-4 {ECO:0000313|Proteomes:UP000002743};
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Clum A., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Kayluzhnaya M., Chistoserdova L.;
RT   "Complete sequence of chromosome of Methylovorus sp. SIP3-4.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACT51290.1, ECO:0000313|Proteomes:UP000002743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SIP3-4 {ECO:0000313|EMBL:ACT51290.1,
RC   ECO:0000313|Proteomes:UP000002743};
RX   PubMed=21622745; DOI=10.1128/JB.00404-11;
RA   Lapidus A., Clum A., Labutti K., Kaluzhnaya M.G., Lim S., Beck D.A.,
RA   Glavina Del Rio T., Nolan M., Mavromatis K., Huntemann M., Lucas S.,
RA   Lidstrom M.E., Ivanova N., Chistoserdova L.;
RT   "Genomes of three methylotrophs from a single niche uncover genetic and
RT   metabolic divergence of Methylophilaceae.";
RL   J. Bacteriol. 193:3757-3764(2011).
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DR   EMBL; CP001674; ACT51290.1; -; Genomic_DNA.
DR   RefSeq; WP_015830637.1; NC_012969.1.
DR   AlphaFoldDB; C6X7W3; -.
DR   STRING; 582744.Msip34_2048; -.
DR   KEGG; mei:Msip34_2048; -.
DR   eggNOG; COG0507; Bacteria.
DR   HOGENOM; CLU_272126_0_0_4; -.
DR   OrthoDB; 1634048at2; -.
DR   Proteomes; UP000002743; Chromosome.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.30.30.940; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014862; TrwC.
DR   Pfam; PF13604; AAA_30; 1.
DR   Pfam; PF08751; TrwC; 1.
DR   SUPFAM; SSF55464; Origin of replication-binding domain, RBD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000313|EMBL:ACT51290.1};
KW   Exonuclease {ECO:0000313|EMBL:ACT51290.1};
KW   Helicase {ECO:0000313|EMBL:ACT51290.1};
KW   Hydrolase {ECO:0000313|EMBL:ACT51290.1};
KW   Nuclease {ECO:0000313|EMBL:ACT51290.1};
KW   Nucleotide-binding {ECO:0000313|EMBL:ACT51290.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002743}.
FT   DOMAIN          207..303
FT                   /note="TrwC relaxase"
FT                   /evidence="ECO:0000259|Pfam:PF08751"
SQ   SEQUENCE   1188 AA;  136121 MW;  E93B4CF18BD20A36 CRC64;
     MGVAINNINY KNGYDFNKYL SSHVLDIEQN IDMHQEYLMK GITATNNVAV EIDTFKMFTR
     SGGELLDALN LSGYLDRNKL NEISKLCVGE HELTKGFKKQ KNKIYRSIVD ADGDEVEVKL
     KDIKRGWYKD ELGNRVAFNV KQVKESSHLT MKVGTEIVLT QDATFSFAIA GMNPQDRYDA
     EQIIQDTAME VYDNIFKDML HDKYFNKGKT GVFLFYHNDS RNPLSPSSHV HMVIPNVIQL
     ADGTIRAVEM PEMRDKNFHD MIDMQYKSRL IQRWNERFKD LPVEAYDKDR QRITSPTQEV
     KDFRVAYDEE SLRKIHDQSV ADELINKYIK YQKDDMRGVV DSKLKIVDQE IVELTKKLSF
     EDKLPTGTLI SHGEDNYFFD AKNTKSYYVK LSVRKPDGKE KEQIYWGVDL KRAIESSKSN
     IGDLVVLEKS KSDPKNPKEK STFNISVDHK NMEILNSIDD LEVKMARINK KYSNQIAYMG
     TTKHRNKVWK VIKERKKGGS IINKTIENKK IHEALAPKIA VDPGIGMKEK KFLEIIETLT
     STTPYINKNA LVYEIAKSSP VGFNAQKMAD ELIAKSLESE LLVATGTLSK TQTAYTTWEL
     INKEYENIEL MKKLHNTEQK YKIYNVKKEI DLVEDKPEYK DKGIKSNKEQ IEMIESVFSD
     RKGQICIGLP GTGKSLSIKI CTEIAHKHGF RTIGCAFTNK VSTALDDETL CDVVKTVDKL
     LHDIESGKLK LNGNDIVFVD EASQIGTRQY NKLLNAVVDA KAKIVLIGDP NQINSINTGN
     TLNEFLRDSE IRDNVVFLTD IRRQKNETAL TVAETSSLKE VYKDEATFRR VKKEGSHVEK
     VFTLLEQAGC VHNKFITNTE TIEAISKAYI NNVNDYKDKL LIAATNESID RINDKIQDRR
     IELGQVVGKP YIAEDSKFFY KGDRIVMEKN TKEYKNGDFG TITNIDPTTN KITIEFDNSK
     TKTFDNPKKI KLSYGITAEK AQGLTTNDTL VYGEASQNVD QERLNVIVTR ARFNTHFFAT
     SSEYEAVKDA CKRESSKESL IDLRNRLIPK NTTITQQSIN EVKPNLVVQN KIEQTNKLTQ
     EVLKNGLSNI KDNTLLNRLE KFRLVDGRPR QHQVFNYKPY MANYKKPPQA ILNQITAKAK
     MINATENRMM NVNDLRVKTI ENKKPEISTV MKPTDIYKKK QTMKMTQK
//