ID C7AFF7_MELGA Unreviewed; 781 AA.
AC C7AFF7;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
GN Name=TLR2B {ECO:0000313|EMBL:ACS92626.1};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|EMBL:ACS92626.1};
RN [1] {ECO:0000313|EMBL:ACS92626.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21619680; DOI=10.1186/1471-2148-11-149;
RA Huang Y., Temperley N.D., Ren L., Smith J., Li N., Burt D.W.;
RT "Molecular evolution of the vertebrate TLR1 gene family - a complex history
RT of gene duplication, gene conversion, positive selection and co-
RT evolution.";
RL BMC Evol. Biol. 11:149-149(2011).
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR EMBL; FJ477861; ACS92626.1; -; Genomic_DNA.
DR AlphaFoldDB; C7AFF7; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..781
FT /note="Toll-like receptor 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002975555"
FT TRANSMEM 586..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 636..779
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 781 AA; 88747 MW; FBA954CA3DBB529A CRC64;
MRTWKVWMIY IALAAHLPEE QALRQACLSC DATQSCNCSS MGLDFIPSGL TGKITALNLA
HNRIKLIRAH DLQQAVNLRA LLLQSNQISS IDEDSFASQG KLELLDLSNN SLARLSPAWF
GPLFSLQHLR IQGNSYSDLG ESSPFSSLRN LNSLHLGNPQ FSVIRQGNFE GITFLSTLKI
DGGNLSQYEP GSLKSIRKIN HMIISVRRID VFSAVIRDLL HSAIWLDVRK LAFSAPEKIQ
FLRIMSSSFT KKISLKQCLF TDATVPGIVS ILEGMPKLME VEMKDCTLLG TGLWYTQIHA
KQSQSLRVLT IKNLSIENFY LFTDLQSVLD LLSLFRKVTV ENTKVFLVPC KLSQQLLSLE
YLDLSANLLG DQSLEHSACQ GAWPSLQTLN LSQNSLSDLK MTGKSLFHLR KLNLLDISEN
NFGEIPDVCE WPEDLEYLNL SSTQIPKLTR CIPSTLEVLD VSANNLQDFG LELPLLKELY
LTKNHLKTLP EAAAIPNLVA MSISRNNLNS FSKKEFASFK QMELLDASAN NFICSCEFLS
FIQHEAGITQ VLVGWPESYI CDSPLAVRGA QVGSVSLSLM ECHRSFLVSL ICILMFLFIL
VLVVIGYKYH AVWYMRMTWA WLQAKRKPKR APTKDICYDA FVSYSENDSN WVENIMVQQL
EQACPPFRLC LHKRDFVPGK WIVDNIIDSI EKSHKTLFVL SEHFVQSEWC KYELDFSHFR
LFDENNDVAI LILLEPIQSQ AIPKRFCKLR KIMNTKTYLE WPPDEEQQQM FWENLKAALK
S
//
