ID C7AIL6_9EUTH Unreviewed; 191 AA.
AC C7AIL6;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=von Willebrand factor {ECO:0000256|ARBA:ARBA00016619};
DE Flags: Fragment;
GN Name=vWF {ECO:0000313|EMBL:ACT79520.1};
OS Tupaia splendidula (ruddy tree shrew).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Scandentia; Tupaiidae; Tupaia.
OX NCBI_TaxID=320362 {ECO:0000313|EMBL:ACT79520.1};
RN [1] {ECO:0000313|EMBL:ACT79520.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20525582; DOI=10.1093/sysbio/syp025;
RA Roberts T.E., Sargis E.J., Olson L.E.;
RT "Networks, trees, and treeshrews: assessing support and identifying
RT conflict with multiple loci and a problematic root.";
RL Syst. Biol. 58:257-270(2009).
CC -!- SUBUNIT: Multimeric. Interacts with F8.
CC {ECO:0000256|ARBA:ARBA00025858}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; FJ555011; ACT79520.1; -; Genomic_DNA.
DR EMBL; FJ555013; ACT79522.1; -; Genomic_DNA.
DR AlphaFoldDB; C7AIL6; -.
DR GO; GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.
DR CDD; cd01450; vWFA_subfamily_ECM; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR032361; VWA_N2.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR22588:SF5; COLLAGEN ALPHA-6(VI) CHAIN; 1.
DR PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR Pfam; PF00092; VWA; 1.
DR Pfam; PF16164; VWA_N2; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 40..191
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACT79520.1"
FT NON_TER 191
FT /evidence="ECO:0000313|EMBL:ACT79520.1"
SQ SEQUENCE 191 AA; 21584 MW; 5A2CE9D65A214A2D CRC64;
QEPGGLVVPP TVVPVSPTTL YVEDTPEPPL HSFHCSRLLD LVFLLDGSSR LSEAEFEVLK
AFVVDMMERL RISQKWIRVA VVEYHEGSHS YIDLKDRKRP SELRHIASQV RYAGSQVASI
SEVLKYTLFQ IFGNIDRPEA SRVALLLTAS QEDPGMVRNL VRYVQGLKKK KVVMVPVSIG
PHTNLRQIRL I
//
