ID C7BHA6_PHOAA Unreviewed; 392 AA.
AC C7BHA6;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Multidrug resistance secretion protein {ECO:0000313|EMBL:CAQ85272.1};
GN Name=emrA {ECO:0000313|EMBL:CAQ85272.1};
GN OrderedLocusNames=PAU_03184 {ECO:0000313|EMBL:CAQ85272.1};
OS Photorhabdus asymbiotica subsp. asymbiotica (strain ATCC 43949 / 3105-77)
OS (Xenorhabdus luminescens (strain 2)).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Photorhabdus.
OX NCBI_TaxID=553480 {ECO:0000313|EMBL:CAQ85272.1, ECO:0000313|Proteomes:UP000002747};
RN [1] {ECO:0000313|EMBL:CAQ85272.1, ECO:0000313|Proteomes:UP000002747}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43949 / 3105-77 {ECO:0000313|Proteomes:UP000002747};
RX PubMed=19583835; DOI=10.1186/1471-2164-10-302;
RA Wilkinson P., Waterfield N.R., Crossman L., Corton C.,
RA Sanchez-Contreras M., Vlisidou I., Barron A., Bignell A., Clark L.,
RA Ormond D., Mayho M., Bason N., Smith F., Simmonds M., Churcher C.,
RA Harris D., Thompson N.R., Quail M., Parkhill J., ffrench-Constant R.H.;
RT "Comparative genomics of the emerging human pathogen Photorhabdus
RT asymbiotica with the insect pathogen Photorhabdus luminescens.";
RL BMC Genomics 10:302-302(2009).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; FM162591; CAQ85272.1; -; Genomic_DNA.
DR AlphaFoldDB; C7BHA6; -.
DR STRING; 291112.PAU_03184; -.
DR KEGG; pay:PAU_03184; -.
DR eggNOG; COG1566; Bacteria.
DR Proteomes; UP000002747; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR005694; MFP_proteobact.
DR NCBIfam; TIGR00998; 8a0101; 1.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..348
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 201..291
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 392 AA; 43497 MW; ACF217D4A16790BE CRC64;
MSANQEVQAP QNPTSSKKRQ RSRALVLLTL VFTLLGVAYF FYWFIVLRHH QETDNAYVTG
NQVQIMSQVA GSVITVHFDN TDFVKSGSVL VQLDPRDAEL ALEKAKTALA SSVRQTHQQM
INSKQYQANI ALRRSELTRV QSDLSRREVL GAQKVIGKEE LQHAREAVAS AKATLDVAVE
QYNANQAVIL DTPLEKQPAV EQAATDVRNA WLALQRTKIV SPVDGYVSRR SVQIGAQINK
NTPLMAIIPA YNMWIEANFK ETQLANMRIG QPAEITSDFY GKDKIFNGKI TGLDMGTGSA
FSLLPAQNAS GNWIKVVQRL PVRIELNPEQ LEKYPLRIGL STKVRVDTTH SDGQVLSNRT
RTKSAYHTTA LTIDMSPANK IVTDIINNNA GK
//
