ID C7BZV7_HELPB Unreviewed; 285 AA.
AC C7BZV7;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=3-hydroxyacid dehydrogenase {ECO:0000313|EMBL:CAX29260.1};
DE EC=1.1.1.- {ECO:0000313|EMBL:CAX29260.1};
GN OrderedLocusNames=HELPY_0730 {ECO:0000313|EMBL:CAX29260.1};
OS Helicobacter pylori (strain B38).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=592205 {ECO:0000313|EMBL:CAX29260.1, ECO:0000313|Proteomes:UP000000313};
RN [1] {ECO:0000313|EMBL:CAX29260.1, ECO:0000313|Proteomes:UP000000313}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B38 {ECO:0000313|EMBL:CAX29260.1,
RC ECO:0000313|Proteomes:UP000000313};
RX PubMed=20537153; DOI=10.1186/1471-2164-11-368;
RA Thiberge J.M., Boursaux-Eude C., Lehours P., Dillies M.A., Creno S.,
RA Coppee J.Y., Rouy Z., Lajus A., Ma L., Burucoa C., Ruskone-Foumestraux A.,
RA Courillon-Mallet A., De Reuse H., Boneca I.G., Lamarque D., Megraud F.,
RA Delchier J.C., Medigue C., Bouchier C., Labigne A., Raymond J.;
RT "From array-based hybridization of Helicobacter pylori isolates to the
RT complete genome sequence of an isolate associated with MALT lymphoma.";
RL BMC Genomics 11:368-368(2010).
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DR EMBL; FM991728; CAX29260.1; -; Genomic_DNA.
DR RefSeq; WP_015828987.1; NC_012973.1.
DR AlphaFoldDB; C7BZV7; -.
DR KEGG; hpb:HELPY_0730; -.
DR HOGENOM; CLU_035117_0_5_7; -.
DR Proteomes; UP000000313; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:CAX29260.1}.
FT DOMAIN 2..158
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 161..280
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 167
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 285 AA; 30545 MW; 8774DA4E0007E3CE CRC64;
MKIGWIGLGA MGTPMATRLC DAGLKVSVYN RTESKAAPLK EKGVAVYTNP IDLAAKVDLI
FIMLSDKTAI DAVLVPEFWE QMSKKIVVNM STIAPLESLD LEKTAQKHQA TYLEAPVSGS
VGAAKAGALL ILAAGEKEVV AQLKPVLVHL GSQTFYLGKI GQGAGAKLSI NSLLAQMGVA
YSEALLLAKH LGVDAELFLQ IIGQSGMNSP LFQAKKGMWL QDSYPVAFSL KLMLKDIRLA
KNEAGEAIQL PFLSKVQELY SQAEKSGLGA LDMAAVYHYL KKGEH
//
