ID C7CHC9_METED Unreviewed; 436 AA.
AC C7CHC9;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=RND efflux transporter, MFP subunit {ECO:0000313|EMBL:CAX26429.1};
GN ORFNames=METD_I4813 {ECO:0000313|EMBL:CAX26429.1};
OS Methylorubrum extorquens (strain DSM 6343 / CIP 106787 / DM4)
OS (Methylobacterium extorquens).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Methylobacteriaceae; Methylorubrum.
OX NCBI_TaxID=661410 {ECO:0000313|EMBL:CAX26429.1, ECO:0000313|Proteomes:UP000008070};
RN [1] {ECO:0000313|Proteomes:UP000008070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6343 / CIP 106787 / DM4
RC {ECO:0000313|Proteomes:UP000008070};
RX PubMed=19440302; DOI=10.1371/journal.pone.0005584;
RA Vuilleumier S., Chistoserdova L., Lee M.-C., Bringel F., Lajus A., Zhou Y.,
RA Gourion B., Barbe V., Chang J., Cruveiller S., Dossat C., Gillett W.,
RA Gruffaz C., Haugen E., Hourcade E., Levy R., Mangenot S., Muller E.,
RA Nadalig T., Pagni M., Penny C., Peyraud R., Robinson D.G., Roche D.,
RA Rouy Z., Saenampechek C., Salvignol G., Vallenet D., Wu Z., Marx C.J.,
RA Vorholt J.A., Olson M.V., Kaul R., Weissenbach J., Medigue C.,
RA Lidstrom M.E.;
RT "Methylobacterium genome sequences: a reference blueprint to investigate
RT microbial metabolism of C1 compounds from natural and industrial sources.";
RL PLoS ONE 4:E5584-E5584(2009).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; FP103042; CAX26429.1; -; Genomic_DNA.
DR RefSeq; WP_015824019.1; NC_012988.1.
DR AlphaFoldDB; C7CHC9; -.
DR GeneID; 72991543; -.
DR KEGG; mdi:METDI4813; -.
DR HOGENOM; CLU_018816_2_1_5; -.
DR Proteomes; UP000008070; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 34..436
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002976711"
FT DOMAIN 57..280
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 399..436
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 106..171
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 436 AA; 45925 MW; 3D70A4B0A86D5748 CRC64;
MTMTGMFTLR VWVAAATLSA ACPPAISTAF AQAEPTGPPV VGIIAARKEP ITQTEQFIGR
IEAKQRVDIV ARVTAFIEKR LFVEGTDVEE GALLYRLEQG PFQAVVAAQK AQIAQVEAQL
ENARLTTQRA RTLLGGPAGQ QSTYDAALAN ERALEAQLQG AQAQLDTAQI NLGYTEIRAP
IAGQIGRTSL TIGNVVGPGS GVLTTIISQD PMFVTFPVPV REAINLRARY GPTGGFGAVL
IRAQLPDGRF YDHTGTLDFV NNTIATNTDT ILLRGVLPNP PIFGQTRSLL TLRELTDGEF
VTVFLEGVEP VEVVAIPRAA VLADQRGSYV YVIGQDNKAE ERRIQLGQSS TTLAAVTSGL
KVGEQVIAEG LQRVRAGETV SPKPADAILQ RMMRNSAVNA DSAGPAASVS PPAGHAPTGA
ASGAGPSASG SPSRRR
//
