ID C7DGQ9_MICA2 Unreviewed; 240 AA.
AC C7DGQ9;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Probable thymidylate kinase {ECO:0000256|HAMAP-Rule:MF_00165};
DE EC=2.7.4.9 {ECO:0000256|HAMAP-Rule:MF_00165};
DE AltName: Full=dTMP kinase {ECO:0000256|HAMAP-Rule:MF_00165};
GN Name=tmk {ECO:0000256|HAMAP-Rule:MF_00165};
GN ORFNames=UNLARM2_0259 {ECO:0000313|EMBL:EET90230.1};
OS Candidatus Micrarchaeum acidiphilum ARMAN-2.
OC Archaea; Candidatus Micrarchaeota; Candidatus Micrarchaeia;
OC Candidatus Micrarchaeales; Candidatus Micrarchaeaceae;
OC Candidatus Micrarchaeum.
OX NCBI_TaxID=425595 {ECO:0000313|EMBL:EET90230.1, ECO:0000313|Proteomes:UP000332487};
RN [1] {ECO:0000313|EMBL:EET90230.1, ECO:0000313|Proteomes:UP000332487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARMAN-2 {ECO:0000313|EMBL:EET90230.1};
RX PubMed=19698104; DOI=10.1186/gb-2009-10-8-r85;
RA Dick G.J., Andersson A.F., Baker B.J., Simmons S.L., Thomas B.C.,
RA Yelton A.P., Banfield J.F.;
RT "Community-wide analysis of microbial genome sequence signatures.";
RL Genome Biol. 10:R85-R85(2009).
RN [2] {ECO:0000313|EMBL:EET90230.1, ECO:0000313|Proteomes:UP000332487}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ARMAN-2 {ECO:0000313|EMBL:EET90230.1};
RX PubMed=20421484; DOI=10.1073/pnas.0914470107;
RA Baker B.J., Comolli L.R., Dick G.J., Hauser L.J., Hyatt D., Dill B.D.,
RA Land M.L., Verberkmoes N.C., Hettich R.L., Banfield J.F.;
RT "Enigmatic, ultrasmall, uncultivated Archaea.";
RL Proc. Natl. Acad. Sci. U.S.A. 107:8806-8811(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00165};
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|HAMAP-Rule:MF_00165}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00165}.
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DR EMBL; GG697239; EET90230.1; -; Genomic_DNA.
DR AlphaFoldDB; C7DGQ9; -.
DR Proteomes; UP000332487; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00165; Thymidylate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018094; Thymidylate_kinase.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW Kinase {ECO:0000256|HAMAP-Rule:MF_00165, ECO:0000313|EMBL:EET90230.1};
KW Nucleotide biosynthesis {ECO:0000256|HAMAP-Rule:MF_00165};
KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00165};
KW Reference proteome {ECO:0000313|Proteomes:UP000332487};
KW Transferase {ECO:0000256|HAMAP-Rule:MF_00165}.
FT DOMAIN 108..222
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 240 AA; 27152 MW; 777EAAECF509F1EC CRC64;
MAQSDKKSFL ISFEGVGAAG KSLQVDMLRR DPDMQKCMSM KIAKGVSRQS MQESLWPFRD
RETERLWVTV LPKVHPGTDM LAFIAAMNEN CLTMKDELAS DQDGKLKVII FDRYIDTALT
HAVARAALAG EHEDGPAIKS LFGTFFALKE HIEWPDLTIV IDTPIEVAEG RAMKRENHGY
SETDRKGFKT ISEAYRKLAS YEPDRVHFID GRKSPEEILS EIKDLIRNKT GAQWKKDTTA
//
