ID C7DYX2_9HIV1 Unreviewed; 210 AA.
AC C7DYX2;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Reverse transcriptase {ECO:0000313|EMBL:ACT33847.1};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:ACT33847.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:ACT33847.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:ACT33847.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19417582; DOI=10.1097/QAD.0b013e32832ac34e;
RA Hosseinipour M.C., van Oosterhout J.J., Weigel R., Phiri S., Kamwendo D.,
RA Parkin N., Fiscus S.A., Nelson J.A., Eron J.J., Kumwenda J.;
RT "The public health approach to identify antiretroviral therapy failure:
RT high-level nucleoside reverse transcriptase inhibitor resistance among
RT Malawians failing first-line antiretroviral therapy.";
RL AIDS 23:1127-1134(2009).
RN [2] {ECO:0000313|EMBL:ACT33847.1}
RP NUCLEOTIDE SEQUENCE.
RA Nelson J.A.E.;
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GQ228293; ACT33847.1; -; Genomic_RNA.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR PANTHER; PTHR41694:SF3; RNA-DIRECTED DNA POLYMERASE-RELATED; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918,
KW ECO:0000313|EMBL:ACT33847.1}; Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral release from host cell {ECO:0000256|ARBA:ARBA00023113};
KW Virion maturation {ECO:0000256|ARBA:ARBA00023113}.
FT DOMAIN 7..197
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ACT33847.1"
FT NON_TER 210
FT /evidence="ECO:0000313|EMBL:ACT33847.1"
SQ SEQUENCE 210 AA; 24485 MW; A780066DC4C79D6D CRC64;
CEEMEKEGKI TKIGPENPYN TPVFAIKKKD STKWRKLVDF RELNKRTQDF WEVQLGIPHP
AGLKKXKSVT VLDVGDAYFS VPLDENFRKY TAFTIPSINN ETPGIRYQYN VLPQGWKGSP
AIFQSSMTKI LEPFRAQNPE IVICQYXDDL YVGSDLEIGK HREKIEELRX HLLKWGFTTP
DKKXQKEPPF LWMGYELHPD KWTVQPIQLP
//
