ID C7FF18_CTEID Unreviewed; 215 AA.
AC C7FF18;
DT 22-SEP-2009, integrated into UniProtKB/TrEMBL.
DT 22-SEP-2009, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=CD8 alpha chain {ECO:0000313|EMBL:ACU30711.1};
OS Ctenopharyngodon idella (Grass carp) (Leuciscus idella).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Xenocyprididae; Xenocypridinae; Ctenopharyngodon.
OX NCBI_TaxID=7959 {ECO:0000313|EMBL:ACU30711.1};
RN [1] {ECO:0000313|EMBL:ACU30711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19922798; DOI=10.1016/j.fsi.2009.11.007;
RA Yang M., Wang Y., Wang X., Chen C., Zhou H.;
RT "Characterization of grass carp (Ctenopharyngodon idellus) Foxp1a/1b/2:
RT evidence for their involvement in the activation of peripheral blood
RT lymphocyte subpopulations.";
RL Fish Shellfish Immunol. 28:289-295(2010).
RN [2] {ECO:0007829|PDB:5Z11}
RP X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 12-139, AND DISULFIDE BONDS.
RA Wang J., Zhang L.;
RT "Crystal Structure of the Grass Carp CD8 alpha alpha Homodimers Indicates a
RT Dramatic Evolution of CD8 from Ectotherms to Endotherms.";
RL Submitted (DEC-2017) to the PDB data bank.
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DR EMBL; GQ355586; ACU30711.1; -; mRNA.
DR PDB; 5Z11; X-ray; 2.35 A; A/B=12-139.
DR PDBsum; 5Z11; -.
DR AlphaFoldDB; C7FF18; -.
DR SMR; C7FF18; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR CDD; cd00099; IgV; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR015468; CD8_asu.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR10441; CD8 ALPHA CHAIN; 1.
DR PANTHER; PTHR10441:SF2; T-CELL SURFACE GLYCOPROTEIN CD8 ALPHA CHAIN; 1.
DR Pfam; PF07686; V-set; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:5Z11};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..215
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002977497"
FT TRANSMEM 161..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..106
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 195..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 33..100
FT /evidence="ECO:0007829|PDB:5Z11"
SQ SEQUENCE 215 AA; 24227 MW; BAA5DBE432CA27BC CRC64;
MYQIYIGFCV SLSLFYGVSA RIYKEGEKVQ VDCDLKQSGT LTFWFRINSK GADYLFSVKS
ADIKENDLNS EHYTVNTNSG KVQLDIKSFK KKTDSGVYVC AAMNSNKLFF GGLTRIEGEP
DPTTIPPKIA TTKPLPVTAT TKSPCLCKKP EPKPRFNCET WILSSLAAGC ALLLILLIFT
ILYCNRLRTR RCPHHYKRQP QPRHAGHAKL PSNHF
//
