ID   C7GDA5_9FIRM            Unreviewed;       492 AA.
AC   C7GDA5;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=ROSINTL182_07906 {ECO:0000313|EMBL:EEV00196.1};
OS   Roseburia intestinalis L1-82.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Roseburia.
OX   NCBI_TaxID=536231 {ECO:0000313|EMBL:EEV00196.1, ECO:0000313|Proteomes:UP000004828};
RN   [1] {ECO:0000313|EMBL:EEV00196.1, ECO:0000313|Proteomes:UP000004828}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=L1-82 {ECO:0000313|EMBL:EEV00196.1,
RC   ECO:0000313|Proteomes:UP000004828};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Nelson J., Hou S., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Nash W.E., Warren W., Chinwalla A.,
RA   Mardis E.R., Wilson R.K.;
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEV00196.1}.
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DR   EMBL; ABYJ02000148; EEV00196.1; -; Genomic_DNA.
DR   RefSeq; WP_006857968.1; NZ_LR027880.1.
DR   AlphaFoldDB; C7GDA5; -.
DR   GeneID; 61433963; -.
DR   HOGENOM; CLU_555072_0_0_9; -.
DR   Proteomes; UP000004828; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
FT   DOMAIN          1..142
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   492 AA;  56655 MW;  0A5441C978641065 CRC64;
     MFDAFISHSS KDKEKIVLEL VQKLEKNNID VWLDANEILA GDTILDAVEK GVATALCTIL
     IITPAFFESF WTPVEIGLAI GQNNNHKLIP VLCNVSVEDI AQRFPMLLSL KYIKLDPDNI
     DLCVDELCSN IIQIKKKYEK DFPEISFHKA VKKFHSCDTP TANTISILLS EYEQIVEINV
     RTAVLHASQI AITIINDLFM RLPIKGNSVD TTIGKLDLIK VSSIGLTENV YEHLKLLSTP
     ALDTNMSLLT NDLDRRKLAE MSMTAILEWY SKYLLHNKII PQDRFEIVWP DDLSYEDFIT
     MYEIDCLVLR EDLIAPPSIT YAWYQYNNYT HIAVRSTETN RIVGYFTVLP VTDQLYEDIQ
     SGYFKDNDLN TDNLRKYDVP DFYKLYIACV CIHPDYQNTS AFRKLYNALL QMMMDLAVER
     EIYITNIITE ASTLQGEKFC KILGLNCMLN TEIETKIYGA TLLPPSWQLR SSFGSKLMKY
     YKEKYEELKD LF
//