ID C7JBQ8_ACEP3 Unreviewed; 884 AA.
AC C7JBQ8;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982};
GN Name=mutS {ECO:0000313|EMBL:BAH99802.1};
GN OrderedLocusNames=APA01_16730 {ECO:0000313|EMBL:BAH99802.1};
OS Acetobacter pasteurianus (strain NBRC 105184 / IFO 3283-01).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Acetobacter.
OX NCBI_TaxID=634452 {ECO:0000313|EMBL:BAH99802.1, ECO:0000313|Proteomes:UP000000948};
RN [1] {ECO:0000313|EMBL:BAH99802.1, ECO:0000313|Proteomes:UP000000948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 105184 / IFO 3283-01 {ECO:0000313|Proteomes:UP000000948};
RX PubMed=19638423; DOI=10.1093/nar/gkp612;
RA Azuma Y., Hosoyama A., Matsutani M., Furuya N., Horikawa H., Harada T.,
RA Hirakawa H., Kuhara S., Matsushita K., Fujita N., Shirai M.;
RT "Whole-genome analyses reveal genetic instability of Acetobacter
RT pasteurianus.";
RL Nucleic Acids Res. 37:5768-5783(2009).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; AP011121; BAH99802.1; -; Genomic_DNA.
DR RefSeq; WP_014456967.1; NC_013209.1.
DR AlphaFoldDB; C7JBQ8; -.
DR STRING; 634452.APA01_16730; -.
DR KEGG; apt:APA01_16730; -.
DR PATRIC; fig|634452.3.peg.1745; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_4_0_5; -.
DR BioCyc; APAS634452:APA01_RS08485-MONOMER; -.
DR Proteomes; UP000000948; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}.
FT DOMAIN 710..726
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 884 AA; 94876 MW; 8787CEEF9276B60F CRC64;
MTRISSKGAT PAMAQWFTLK AENPEALLFF RMGDFYELFF DDATAAAAAL DIALTARGTH
AGEPIPMCGV PVAAAPAYLA RLIRRGFRVA VAEQTETPRK GRSANKGPLA RGVVRVITPG
TLTEDELLEP GRSNLLLALA LTAPQTKGKG KKAEASFADT VIGAAWIDVS TGLFETESLT
GKGLPALLGR LDPAEILAPA ILNLADYEAR RAPETVASGA DTARQRLASA FDVASIEAFG
TFTDEESVAA AMAVEYVQRS QAGKLPRLAH PVPQNESGIL GIDPATRASL DILRARDGGD
EHTLFSAVNR TVSAAGARML AEWLAAPLTH AGQIAARQEG WWWLKEDALR REALRGTLKK
APDIARALGR LSLGRGQPRD LAAMRDGLMV AREAARILTA ADASLPPALH QAVTRLGGGQ
ALEAELARAL AENLPARLDD GGVIAQGYDA KLDEYRGLRD DSRRLIAGLQ AKYAAHYGLN
SLKIRHHAQL GYVMEVPVAA SAKLKDKPEL ILRQGTASNA RFATEELSTL DARITEAAEK
ASQREKELFG ALVEQVLAER SMPVLAQALA VLDVLQSCAD LAGNGTWCRP EVTEDFAFAL
EGCRHPVVEA ALPAGTRFTP NTCDLAPQQR VMLLTGPNMA GKSTYLRQTA LAVILAQGGF
PVPADRVRIG VVDQLFSRVG ASDDLARGRS TFMVEMTETA AILNQAGPRS LVVVDEIGRG
TATLDGLAIA WAVLEALHSS VRCRAIFATH FHELSRLVDT LPRLSLHTMA VREWRGQIVF
LHEVLAGSAK KSWGVHVARL AGVPHAVVDR AGRLLRELER AENTIPEPLP LFDTQKTLPP
EPQNTLSKRL MDIDPDSLTP RAALDLLYEL RKEAAQEDHA QAAG
//
