ID C7NRX5_HALUD Unreviewed; 707 AA.
AC C7NRX5;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Archaeal Rqc2 homolog aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
DE Short=aRqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN Name=rqcH {ECO:0000256|HAMAP-Rule:MF_00844};
GN OrderedLocusNames=Huta_2928 {ECO:0000313|EMBL:ACV13089.1};
OS Halorhabdus utahensis (strain DSM 12940 / JCM 11049 / AX-2).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Haloarculaceae; Halorhabdus.
OX NCBI_TaxID=519442 {ECO:0000313|EMBL:ACV13089.1, ECO:0000313|Proteomes:UP000002071};
RN [1] {ECO:0000313|EMBL:ACV13089.1, ECO:0000313|Proteomes:UP000002071}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12940 / JCM 11049 / AX-2
RC {ECO:0000313|Proteomes:UP000002071};
RX PubMed=21304660; DOI=10.4056/sigs.31864;
RA Anderson I., Tindall B.J., Pomrenke H., Goker M., Lapidus A., Nolan M.,
RA Copeland A., Glavina Del Rio T., Chen F., Tice H., Cheng J.F., Lucas S.,
RA Chertkov O., Bruce D., Brettin T., Detter J.C., Han C., Goodwin L.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.D., Pitluck S., Pati A.,
RA Mavromatis K., Ivanova N., Ovchinnikova G., Chen A., Palaniappan K.,
RA Chain P., Rohde M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P.;
RT "Complete genome sequence of Halorhabdus utahensis type strain (AX-2).";
RL Stand. Genomic Sci. 1:218-225(2009).
CC -!- FUNCTION: Probably part of the ribosome quality control system (RQC).
CC May mediate the addition of alanine residues (Ala tailing) to
CC incompletely synthesized nascent chains from stalled ribosomes, leading
CC to their degradation. {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SUBUNIT: Associates with stalled 50S ribosomal subunits.
CC {ECO:0000256|HAMAP-Rule:MF_00844}.
CC -!- SIMILARITY: Belongs to the NEMF family. {ECO:0000256|HAMAP-
CC Rule:MF_00844}.
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DR EMBL; CP001687; ACV13089.1; -; Genomic_DNA.
DR RefSeq; WP_015790651.1; NC_013158.1.
DR AlphaFoldDB; C7NRX5; -.
DR STRING; 519442.Huta_2928; -.
DR GeneID; 8385237; -.
DR KEGG; hut:Huta_2928; -.
DR eggNOG; arCOG01695; Archaea.
DR HOGENOM; CLU_003612_2_1_2; -.
DR OrthoDB; 10943at2157; -.
DR Proteomes; UP000002071; Chromosome.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR HAMAP; MF_00844_A; RqcH_A; 1.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR InterPro; IPR043681; RqcH_archaeal.
DR NCBIfam; NF041120; RqcH_arch; 1.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_00844};
KW Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00844};
KW Reference proteome {ECO:0000313|Proteomes:UP000002071};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_00844};
KW tRNA-binding {ECO:0000256|HAMAP-Rule:MF_00844}.
FT DOMAIN 497..614
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT REGION 448..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 309..343
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00844"
FT COMPBIAS 459..474
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 79197 MW; AC6BBF6F231D8F9E CRC64;
MDRKRELTSV DCAALAGELR AFVGAYHEKS YLYDDDLLRL KLSGPNFGRI ELLIEVDDPK
RVHTITPDRV PNAPERPPNF AMMLRNRLEG AQLESVEQFE FDRILQLRFE RSDDHTTIIA
ELFGDGNLAV LDETDTVIDS LETVRLQSRT VTPGSQYEFP SARFNPLTVE YETFVERMRQ
SDADVVRTLA TQLNFGGLYG EELCSRAGVP YNQAIGETTD AEFEALYDAV NDLSTRLREG
DLDPRLYFET DEQETPVDVT PVPLVEYEDT PGESFDSFND ALEAYFLGLE QEPDEEETGS
NRPDFEAEIE KQKRIIQQQE GAIEDFEEDA EAEREKAELL YANYDLVDEV LSTVQDARAA
ETPWDEIEAT LSAGKDQGIP AAEAVRDVDG SEGTVTVQID DHHIELDADT GVEKNADRLY
QEAKRIEGKK AGAEEAIANT REQLEAVKQR REAWEASDGD DGGDGSGETH EDDQEDVDWL
TRESIPIRTS EEWYERFRWF TTSDGFLVIG GRNADQNEEL VKKYLDRGDL FFHTQAHGAP
ATILKATGPS EAPPDDISIP ESSREEAAQF AISYSTLWKE GKYAGDVYCV GPDQVTKTPE
SGEYLEKGSF AIRGDRTYYD DTPVGVAVGI TCEPETRVIG GPPSAIDGQA ETTIEVEPGR
YAQNDIAKRL YREFKGRFAD DTFVRKVASP DLIQEFLPAG GSRMVEE
//
