ID C7R1Z5_JONDD Unreviewed; 521 AA.
AC C7R1Z5;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Jden_2248 {ECO:0000313|EMBL:ACV09883.1};
OS Jonesia denitrificans (strain ATCC 14870 / DSM 20603 / BCRC 15368 / CIP
OS 55.134 / JCM 11481 / NBRC 15587 / NCTC 10816 / Prevot 55134) (Listeria
OS denitrificans).
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Jonesiaceae;
OC Jonesia.
OX NCBI_TaxID=471856 {ECO:0000313|EMBL:ACV09883.1, ECO:0000313|Proteomes:UP000000628};
RN [1] {ECO:0000313|EMBL:ACV09883.1, ECO:0000313|Proteomes:UP000000628}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14870 / DSM 20603 / BCRC 15368 / CIP 55.134 / JCM 11481 /
RC NBRC 15587 / NCTC 10816 / Prevot 55134
RC {ECO:0000313|Proteomes:UP000000628};
RX PubMed=21304666; DOI=10.4056/sigs.41646;
RA Pukall R., Gehrich-Schroter G., Lapidus A., Nolan M., Glavina Del Rio T.,
RA Lucas S., Chen F., Tice H., Pitluck S., Cheng J.F., Copeland A.,
RA Saunders E., Brettin T., Detter J.C., Bruce D., Goodwin L., Pati A.,
RA Ivanova N., Mavromatis K., Ovchinnikova G., Chen A., Palaniappan K.,
RA Land M., Hauser L., Chang Y.J., Jeffries C.D., Chain P., Goker M.,
RA Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C.,
RA Klenk H.P., Han C.;
RT "Complete genome sequence of Jonesia denitrificans type strain (Prevot
RT 55134).";
RL Stand. Genomic Sci. 1:262-269(2009).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001706; ACV09883.1; -; Genomic_DNA.
DR RefSeq; WP_015772511.1; NC_013174.1.
DR AlphaFoldDB; C7R1Z5; -.
DR STRING; 471856.Jden_2248; -.
DR REBASE; 21835; M.JdeORF2248P.
DR KEGG; jde:Jden_2248; -.
DR eggNOG; COG0286; Bacteria.
DR HOGENOM; CLU_013049_4_1_11; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000000628; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ACV09883.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000628};
KW Transferase {ECO:0000313|EMBL:ACV09883.1}.
FT DOMAIN 13..150
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 164..481
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 521 AA; 58649 MW; 0EF502E645468EEF CRC64;
MARAAKPKPT KTLEQTLWEA ADKLRGNQEP SEYKHVVLGL VFLKYISDRF EERRATLEAE
LAAEGIKPER LPDFLEDRDE YTSHNVFWVP ELARWGYIQS VAKQPEIGQQ IDQAMDLIEK
ENPTLRGVLP RNYGRDGLDK RRLGELVDLI GSIGFTETDD HGADDVLGRV YEYFLGQFAG
KETGKDAGAF YTPRSVVKTL VEMLEPYQGR VYDPAAGSGG MFVQSAEFVK AHGGKRTDIS
VYGQEFTDTT WKLSKMNLAL RGIEADMGPR SADSFTDDLH PDLRADFVIA NPPFNVSDWW
DAKLEGDPRW QYGTPPQGNA NFAWVQHFIY HLSPKGTAGF VLANGSLSSK SGGEGEMRRK
LVEADLVDCI VAMPDKLFFN TGIPVALWFV SKARHGNGHR ERRSEVLFID ARKLGTMESR
RLRVLTDDDI AKIADTYHAW RNHDGGYEDV PGFAKAASLE EIAKHDYVLT PGRYVGAAEA
EVDDEPIDEK IERLTKELFA EFERGRELED EVRQRLSGVQ P
//
