ID C7S4I4_GAMWI Unreviewed; 236 AA.
AC C7S4I4;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BNDF {ECO:0000313|EMBL:ABW84408.1};
OS Gambelia wislizenii (Long-nosed leopard lizard) (Crotaphytus wislizenii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Iguanidae; Crotaphytinae; Gambelia.
OX NCBI_TaxID=43593 {ECO:0000313|EMBL:ABW84408.1};
RN [1] {ECO:0000313|EMBL:ABW84408.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=I1 {ECO:0000313|EMBL:ABW84408.1};
RA Pramuk J.B., Bezy R.L., Noonan B.P., de Queiroz K., Sites J.W.Jr.;
RT "Phylogenetic relationships within the Xantusiidae (Squamata): using trees
RT to address evolutionary questions at multiple levels.";
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; EU108358; ABW84408.1; -; Genomic_DNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 125..232
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 133..200
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 178..229
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 188..231
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 236
FT /evidence="ECO:0000313|EMBL:ABW84408.1"
SQ SEQUENCE 236 AA; 26563 MW; 20C23BB62954822B CRC64;
MVISYFSCMK AAPMKEVSLR GQGSLAYPGL RTQGNLENLG GPNDATRGLT SLADTFEXVI
EELLDEEQAI QPSKENKDAD LYSSRVMLSS QVPLEPPLLF LLEEYKNYLD AANMSMRVRR
HSDPARRGEL SVCDSTSEWV TAAEKKTAVD MSGATVTVLE KVPVPKGQLK QYFYETKCNS
KGYTKEGCRG IDKRYWNSQC RTTQSYVRAL TMDNKKRVGW RFIRIDTSCV CTLTIK
//
