ID C7XXB5_9LACO Unreviewed; 276 AA.
AC C7XXB5;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Pur operon repressor {ECO:0000256|ARBA:ARBA00018449};
GN Name=purR {ECO:0000313|EMBL:EEU29935.1};
GN ORFNames=HMPREF0501_01400 {ECO:0000313|EMBL:EEU29935.1};
OS Limosilactobacillus coleohominis 101-4-CHN.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Limosilactobacillus.
OX NCBI_TaxID=575594 {ECO:0000313|EMBL:EEU29935.1, ECO:0000313|Proteomes:UP000003987};
RN [1] {ECO:0000313|EMBL:EEU29935.1, ECO:0000313|Proteomes:UP000003987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=101-4-CHN {ECO:0000313|EMBL:EEU29935.1,
RC ECO:0000313|Proteomes:UP000003987};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Liu Y., Xu Q., Lander E., Nusbaum C., Galagan J., Birren B.;
RT "The Genome Sequence of Lactobacillus coleohominis strain 101-4-CHN.";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC family. {ECO:0000256|ARBA:ARBA00008391}.
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DR EMBL; GG698805; EEU29935.1; -; Genomic_DNA.
DR RefSeq; WP_006917297.1; NZ_GG698805.1.
DR AlphaFoldDB; C7XXB5; -.
DR STRING; 575594.HMPREF0501_01400; -.
DR eggNOG; COG0503; Bacteria.
DR HOGENOM; CLU_088227_0_0_9; -.
DR OrthoDB; 4213751at2; -.
DR Proteomes; UP000003987; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0045982; P:negative regulation of purine nucleobase metabolic process; IEA:InterPro.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR015265; PuR_N.
DR InterPro; IPR010078; PurR_Bsub.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01743; purR_Bsub; 1.
DR PANTHER; PTHR43864; HYPOXANTHINE/GUANINE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR43864:SF2; PUR OPERON REPRESSOR; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR Pfam; PF09182; PuR_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000003987};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 4..73
FT /note="Bacterial purine repressor N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09182"
FT DOMAIN 109..250
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
SQ SEQUENCE 276 AA; 30584 MW; 7E0789CCB217AECA CRC64;
MKVRRSNRLV DMTRYLLDHP RELVSLKFFG HRYDSAKSSI SEDLSIIRNT VERWGVGRLE
TLPGASGGAR LTPLYSKKNA ATVIDELVQA VNDDSRLLPG GYVYLSDLLG RPDILREVGR
LIATQYVDQD VDVIMTVETK GIPIAQSVAM YLNRPFVIVR NSSHITEGST VSVNYVSGSS
QRIKKMELSR RTMKEGANVV VVDDFLKGGG TMNGMKSLIQ EFGAHLVGMT AFAEGQFDGE
RLVEDCTSLI KVDAQDGVNR HLSAQPGNYL EKVFKK
//
