ID C8C500_9ENTO Unreviewed; 857 AA.
AC C8C500;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Genome polyprotein {ECO:0000256|ARBA:ARBA00020107};
DE Flags: Fragment;
OS Echovirus E6.
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
OC Picornavirales; Picornaviridae; Ensavirinae; Enterovirus; Enterovirus B.
OX NCBI_TaxID=12062 {ECO:0000313|EMBL:ACV04423.1};
RN [1] {ECO:0000313|EMBL:ACV04423.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E6-F3094/BLR/2004 {ECO:0000313|EMBL:ACV04423.1};
RA Dziadziulia K.L., Amvrosieva T.V., Paklonskaya N.V., Biazruchka A.,
RA Bohush Z.F., Kazinetz O.N.;
RT "Potential cardiovirulence determinants of the Enteroviruses causing
RT myocarditis.";
RL Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of immature procapsids, which is cleaved into
CC capsid proteins VP4 and VP2 after maturation (By similarity). Allows
CC the capsid to remain inactive before the maturation step.
CC {ECO:0000256|ARBA:ARBA00025202}.
CC -!- SUBUNIT: Interacts with capsid protein VP1 and capsid protein VP3 to
CC form heterotrimeric protomers. {ECO:0000256|ARBA:ARBA00011474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
CC -!- SIMILARITY: Belongs to the picornaviruses polyprotein family.
CC {ECO:0000256|ARBA:ARBA00008303}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GQ370504; ACV04423.1; -; Genomic_RNA.
DR MEROPS; N08.001; -.
DR GO; GO:0019028; C:viral capsid; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0044694; P:pore-mediated entry of viral genome into host cell; IEA:UniProtKB-KW.
DR GO; GO:0039657; P:suppression by virus of host gene expression; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR CDD; cd00205; rhv_like; 3.
DR Gene3D; 2.60.120.20; -; 3.
DR Gene3D; 4.10.80.10; Picornavirus coat protein VP4; 1.
DR InterPro; IPR003138; Pico_P1A.
DR InterPro; IPR036988; Pico_P1A_sf.
DR InterPro; IPR001676; Picornavirus_capsid.
DR InterPro; IPR033703; Rhv-like.
DR InterPro; IPR029053; Viral_coat.
DR Pfam; PF02226; Pico_P1A; 1.
DR Pfam; PF00073; Rhv; 3.
DR SUPFAM; SSF88633; Positive stranded ssRNA viruses; 2.
PE 3: Inferred from homology;
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561};
KW Eukaryotic host gene expression shutoff by virus
KW {ECO:0000256|ARBA:ARBA00023247};
KW Eukaryotic host translation shutoff by virus
KW {ECO:0000256|ARBA:ARBA00022809};
KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Myristate {ECO:0000256|ARBA:ARBA00022707};
KW Pore-mediated penetration of viral genome into host cell
KW {ECO:0000256|ARBA:ARBA00023255};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral penetration into host cytoplasm {ECO:0000256|ARBA:ARBA00022595};
KW Virion {ECO:0000256|ARBA:ARBA00022561};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 93..300
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 359..524
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT DOMAIN 613..782
FT /note="Picornavirus capsid"
FT /evidence="ECO:0000259|Pfam:PF00073"
FT REGION 837..857
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 857
FT /evidence="ECO:0000313|EMBL:ACV04423.1"
SQ SEQUENCE 857 AA; 95542 MW; 4E4D540D9979C870 CRC64;
MGAQVSTQKT GAHETGLNAS GNSIIHYTNI NYYKDAASNS ANRQDFTQDP GKFTEPVKDI
MVKTLPALNS PSAEECCYRD RVRSITLGNS TITTQESANV VVGYGVWPDY LSDGEATAGD
QPTQPDVATC RFYTLDSVSW MKGSQGWWWK FPDALRDMGL FGQNMQYHYL GRSGYTIHVQ
CDASKFHQGC LLVVCVPEAE MGAAKINEKI NREHLSNGEV ANTFSGTKSS NTNDVQQAVF
NAGMGVAVGN LTIFPHQWIN LRTNNCATIV MPYINSVPMD NMFRHYNFTL MIIPFAKLDY
AAGSSTYIPI TVTVAPMCVE YNGLRLAGHQ GLPVLNTPGS NQFLTSDDYQ SPTAMPQFDV
TPEMNIPGEV RNLMEIAEVD SVVPVNNVNE NVNSLEAYRI PVHSVTETGS QVFGFTLQPG
ADTVMERTLL GEILNYYANW SGSIKLTFMY CGSAMATGKF LLAYSPPGAG VPKNRKEAML
GTHIIWDIGL QSSCVLCVPW ISQTHYRFVS KDNYTDAGFI TCWYQTSIVV PAEVQNQSVI
LCFVSACNDF SVRLLRDSPF VSQTAFYQND VQNAIDRAVV RVADTMPSGP SNSESIPALT
AAETGHTSQV VPSDTIQTRH VKNFHVRSES SVENFLSRSA CVYIVEYKTR DDTPDKMYDS
WVINTRQVAQ LRRKLEFFTY VRFDVEVTFV ITSVQDDSTR QNTDTPALTH QIMYVPPGGP
IPRAVDDYNW QTSTNPSVFW TEGNAPPRMS IPFMSVGNAY SNFYDGWSHF SQTGVYGFNT
LNNMGKLYFR HVNDKTISPI TSKVRIYFKP KHVKAWVPRP PRLCEYTHKD NVDFEPKGVT
TSRSQLTISN STHMENH
//
