UniProt: C8CGM2

Database: UniProt
Entry: C8CGM2_ECOLX

LinkDB:  C8CGM2_ECOLX 
Original site:  C8CGM2_ECOLX

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   EMBL (5)   
Protein domain (10)   
   InterPro (6)   
   Pfam (3)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (22)   

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ID   C8CGM2_ECOLX            Unreviewed;       330 AA.
AC   C8CGM2;
DT   13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT   13-OCT-2009, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=DNA polymerase V protein ImpB {ECO:0000313|EMBL:SPD98987.1};
DE            EC=2.7.7.7 {ECO:0000313|EMBL:SPD98987.1};
DE   SubName: Full=DNA repair protein UmuC {ECO:0000313|EMBL:ACU68792.1};
DE   SubName: Full=Truncated ImpB protein {ECO:0000313|EMBL:STE82130.1};
GN   Name=umuC {ECO:0000313|EMBL:ACU68792.1};
GN   Synonyms=impB {ECO:0000313|EMBL:SPD98987.1}, umuC_2
GN   {ECO:0000313|EMBL:STF37365.1}, umuC_4 {ECO:0000313|EMBL:STE82130.1},
GN   umuC_5 {ECO:0000313|EMBL:STK66844.1};
GN   ORFNames=NCTC10764_06204 {ECO:0000313|EMBL:STE82130.1}, NCTC7928_00035
GN   {ECO:0000313|EMBL:STF37365.1}, NCTC9045_05927
GN   {ECO:0000313|EMBL:STK66844.1}, pEC14_58 {ECO:0000313|EMBL:ACU68792.1},
GN   RCS51_P0007 {ECO:0000313|EMBL:SPD98987.1};
OS   Escherichia coli.
OG   Plasmid RCS51_p {ECO:0000313|EMBL:SPD98987.1}, and
OG   Plasmid pEC14_114 {ECO:0000313|EMBL:ACU68792.1}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562 {ECO:0000313|EMBL:ACU68792.1};
RN   [1] {ECO:0000313|EMBL:ACU68792.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EC14 {ECO:0000313|EMBL:ACU68792.1};
RC   PLASMID=pEC14_114 {ECO:0000313|EMBL:ACU68792.1};
RX   PubMed=19887083; DOI=10.1016/j.plasmid.2009.10.003;
RA   Debroy C., Sidhu M.S., Sarker U., Jayarao B.M., Stell A.L., Bell N.P.,
RA   Johnson T.J.;
RT   "Complete sequence of pEC14_114, a highly conserved IncFIB/FIIA plasmid
RT   associated with uropathogenic Escherichia coli cystitis strains.";
RL   Plasmid 0:0-0(2009).
RN   [2] {ECO:0000313|EMBL:ACU68792.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EC14 {ECO:0000313|EMBL:ACU68792.1};
RC   PLASMID=pEC14_114 {ECO:0000313|EMBL:ACU68792.1};
RA   DebRoy C., Sidhu M.S., Sarker U., Jayarao B.M., Stell A.L., Johnson T.J.;
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:SPD98987.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=666 {ECO:0000313|EMBL:SPD98987.1};
RC   PLASMID=RCS51_p {ECO:0000313|EMBL:SPD98987.1};
RA   Cohen D.B., Kent A.D.;
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Proteomes:UP000254503, ECO:0000313|Proteomes:UP000254877}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC10764 {ECO:0000313|EMBL:STE82130.1,
RC   ECO:0000313|Proteomes:UP000255201}, NCTC7928
RC   {ECO:0000313|EMBL:STF37365.1, ECO:0000313|Proteomes:UP000254877}, and
RC   NCTC9045 {ECO:0000313|EMBL:STK66844.1,
RC   ECO:0000313|Proteomes:UP000254503};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC       {ECO:0000256|ARBA:ARBA00010945}.
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DR   EMBL; GQ398086; ACU68792.1; -; Genomic_DNA.
DR   EMBL; LT985252; SPD98987.1; -; Genomic_DNA.
DR   EMBL; UFZL01000004; STE82130.1; -; Genomic_DNA.
DR   EMBL; UGAB01000001; STF37365.1; -; Genomic_DNA.
DR   EMBL; UGDD01000003; STK66844.1; -; Genomic_DNA.
DR   RefSeq; YP_003162551.1; NC_013175.1.
DR   PATRIC; fig|562.7268.peg.4956; -.
DR   OMA; NHTEQLM; -.
DR   Proteomes; UP000254503; Unassembled WGS sequence.
DR   Proteomes; UP000254877; Unassembled WGS sequence.
DR   Proteomes; UP000255201; Unassembled WGS sequence.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0009432; P:SOS response; IEA:UniProt.
DR   CDD; cd01700; PolY_Pol_V_umuC; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.40.1170.60; -; 1.
DR   Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR   Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR   InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR   InterPro; IPR024728; PolY_HhH_motif.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR001126; UmuC.
DR   PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR   PANTHER; PTHR11076:SF34; PROTEIN UMUC; 1.
DR   Pfam; PF00817; IMS; 1.
DR   Pfam; PF11799; IMS_C; 1.
DR   Pfam; PF11798; IMS_HHH; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50173; UMUC; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000313|EMBL:SPD98987.1};
KW   Plasmid {ECO:0000313|EMBL:ACU68792.1};
KW   Transferase {ECO:0000313|EMBL:SPD98987.1}.
FT   DOMAIN          2..189
FT                   /note="UmuC"
FT                   /evidence="ECO:0000259|PROSITE:PS50173"
SQ   SEQUENCE   330 AA;  36960 MW;  4AA2D49A4579BD6B CRC64;
     MFALADINSF YASCEKVFRP DLRNEPVIVL SNNDGCVIAR SPEAKALGIR MGQPWFQVRQ
     MRLEKKIHVF SSNYALYHSM SQRVMAVLES LSPAVEPYSI DEMFIDLRGI NHCISPEFFG
     HQLREQVKSW TGLTMGVGIA PTKTLAKSAQ WATKQWPQFS GVVALTAENR NRILKLLGLQ
     PVGEVWGVGR RLTEKLNALG INTALQLAQA NTAFIRKNFS VILERTVREL NGESSISLEE
     VPPAKQQIVC SRSFGERITD KDAMHQAVVQ YAERAAEKLR GERQYCRQVT TFVRTSPFAV
     KEPCYSNAAV EKLSLPHRTA GTLLPPHAES
//

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