ID C8NEP0_9LACT Unreviewed; 267 AA.
AC C8NEP0;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Global transcriptional regulator CodY {ECO:0000256|ARBA:ARBA00034538, ECO:0000256|HAMAP-Rule:MF_00621};
GN Name=codY {ECO:0000256|HAMAP-Rule:MF_00621,
GN ECO:0000313|EMBL:EEW37872.1};
GN ORFNames=HMPREF0444_0385 {ECO:0000313|EMBL:EEW37872.1};
OS Granulicatella adiacens ATCC 49175.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC Granulicatella.
OX NCBI_TaxID=638301 {ECO:0000313|EMBL:EEW37872.1, ECO:0000313|Proteomes:UP000005926};
RN [1] {ECO:0000313|EMBL:EEW37872.1, ECO:0000313|Proteomes:UP000005926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49175 {ECO:0000313|EMBL:EEW37872.1,
RC ECO:0000313|Proteomes:UP000005926};
RA Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA Petrosino J., Highlander S., Gibbs R.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-binding global transcriptional regulator which is
CC involved in the adaptive response to starvation and acts by directly or
CC indirectly controlling the expression of numerous genes in response to
CC nutrient availability. During rapid exponential growth, CodY is highly
CC active and represses genes whose products allow adaptation to nutrient
CC depletion. {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00621}.
CC -!- SIMILARITY: Belongs to the CodY family. {ECO:0000256|HAMAP-
CC Rule:MF_00621}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEW37872.1}.
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DR EMBL; ACKZ01000009; EEW37872.1; -; Genomic_DNA.
DR RefSeq; WP_005605445.1; NZ_GG694015.1.
DR AlphaFoldDB; C8NEP0; -.
DR STRING; 638301.HMPREF0444_0385; -.
DR eggNOG; COG4465; Bacteria.
DR HOGENOM; CLU_089581_0_0_9; -.
DR Proteomes; UP000005926; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00621; HTH_type_CodY; 1.
DR InterPro; IPR014154; CodY.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR013198; GTP_trans_reg_CodY_C.
DR InterPro; IPR010312; Transc_reg_CodY_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR40062:SF1; GLOBAL TRANSCRIPTIONAL REGULATOR CODY; 1.
DR PANTHER; PTHR40062; GTP-SENSING TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY; 1.
DR Pfam; PF06018; CodY; 1.
DR Pfam; PF08222; HTH_CodY; 1.
DR PIRSF; PIRSF011572; GTP_sensing_CodY; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00621};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00621}; Reference proteome {ECO:0000313|Proteomes:UP000005926};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|HAMAP-Rule:MF_00621};
KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|HAMAP-
KW Rule:MF_00621};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, ECO:0000256|HAMAP-
KW Rule:MF_00621}.
FT DOMAIN 4..185
FT /note="Global transcriptional regulator CodY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06018"
FT DOMAIN 207..260
FT /note="Global transcriptional regulator CodY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08222"
FT DNA_BIND 210..229
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
FT REGION 1..162
FT /note="GAF domain"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00621"
SQ SEQUENCE 267 AA; 30617 MW; 7B2DD688CFD01EF4 CRC64;
MRKVLADLRK INEIVQYDNI WRDSETADLP FNKLTEILGT LLKVDLYIAS SDGRLLGIHD
EFQVNNDRMK EYKNSRQFPD FYMDGLTSLK FTKENIPVTD ELTIFPVELH DNFKNAMTTI
IPIFASGIQL GFVVMGKDEE PFSTDDLILA EHAGTVIGTE MLHWYTRKIE QEKREQQNVH
LALSSLSYSE LEAIKVIIQL FDGMDLRFTA LKIAKEYNIT RTVIVNAIRK LESAGIIESR
SLGTKGTYIK IKNQNIKKSL LTELKHS
//
