ID   C8NGQ2_9LACT            Unreviewed;      1480 AA.
AC   C8NGQ2;
DT   03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT   03-NOV-2009, sequence version 1.
DT   24-JAN-2024, entry version 50.
DE   SubName: Full=Gram-positive signal peptide protein, YSIRK family {ECO:0000313|EMBL:EEW36879.1};
GN   ORFNames=HMPREF0444_1097 {ECO:0000313|EMBL:EEW36879.1};
OS   Granulicatella adiacens ATCC 49175.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
OC   Granulicatella.
OX   NCBI_TaxID=638301 {ECO:0000313|EMBL:EEW36879.1, ECO:0000313|Proteomes:UP000005926};
RN   [1] {ECO:0000313|EMBL:EEW36879.1, ECO:0000313|Proteomes:UP000005926}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49175 {ECO:0000313|EMBL:EEW36879.1,
RC   ECO:0000313|Proteomes:UP000005926};
RA   Muzny D., Qin X., Deng J., Jiang H., Liu Y., Qu J., Song X.-Z., Zhang L.,
RA   Thornton R., Coyle M., Francisco L., Jackson L., Javaid M., Korchina V.,
RA   Kovar C., Mata R., Mathew T., Ngo R., Nguyen L., Nguyen N., Okwuonu G.,
RA   Ongeri F., Pham C., Simmons D., Wilczek-Boney K., Hale W., Jakkamsetti A.,
RA   Pham P., Ruth R., San Lucas F., Warren J., Zhang J., Zhao Z., Zhou C.,
RA   Zhu D., Lee S., Bess C., Blankenburg K., Forbes L., Fu Q., Gubbala S.,
RA   Hirani K., Jayaseelan J.C., Lara F., Munidasa M., Palculict T., Patil S.,
RA   Pu L.-L., Saada N., Tang L., Weissenberger G., Zhu Y., Hemphill L.,
RA   Shang Y., Youmans B., Ayvaz T., Ross M., Santibanez J., Aqrawi P.,
RA   Gross S., Joshi V., Fowler G., Nazareth L., Reid J., Worley K.,
RA   Petrosino J., Highlander S., Gibbs R.;
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EEW36879.1}.
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DR   EMBL; ACKZ01000020; EEW36879.1; -; Genomic_DNA.
DR   STRING; 638301.HMPREF0444_1097; -.
DR   eggNOG; COG4932; Bacteria.
DR   HOGENOM; CLU_249674_0_0_9; -.
DR   Proteomes; UP000005926; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.530.10; Major cell-surface adhesin PAc; 2.
DR   InterPro; IPR036234; SA_I/II_PAC_V_sf.
DR   InterPro; IPR005877; YSIRK_signal_dom.
DR   NCBIfam; TIGR01168; YSIRK_signal; 1.
DR   Pfam; PF04650; YSIRK_signal; 1.
DR   SUPFAM; SSF74914; V-region of surface antigen I/II (SA I/II, PAC); 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005926};
KW   Signal {ECO:0000256|ARBA:ARBA00022729};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        1455..1472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          15..38
FT                   /note="YSIRK Gram-positive signal peptide"
FT                   /evidence="ECO:0000259|Pfam:PF04650"
FT   REGION          48..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..118
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1480 AA;  167565 MW;  B98A605D8E16161A CRC64;
     MGGNHLKSYK EMLGKKEKFS IRKTSLGVFS IMIGANLLLL PGVAADEVPS EQVTPTTSAS
     ETTEMELRES VARPEPGKSI NDQPNQVRPN LDPVSPEDQE KDRTNTPRIP EDNREYPESN
     EYTNVGVSDP RDVEVKGATK RLVLNDIPNS GLSSAYYNAI EKAKKAGFEI EYTDRVVSSS
     DDISRESSYE ANIIENFIEN NRERLQNYKK NRISNRLQYE RESKEHEHAF EDFQSYQFEG
     NDLRQAVRNQ TVIRGYEYGA KTIVTASEYY PAEAVKYINS LDELSFKNVQ TTANAPEEHS
     NGQVAVLKQG QPVTVSERGL EGTYLTVDGE RKQVTRMDHE YTLVSSPYEE QKALLWIKNV
     GGKLSVTAGA DRATDKPLTI NVKIRYYDEN GHEIVNNTGS NLYAISDLTH GTSRKVLDSY
     TPTGLVARIQ YNDQIEDQYM NYSQAYMSQW SVYRRDENQK VTFHRVQGWT ETHTPILGDE
     ITEEVIPETD AQGVVKGHYH ISRDKGYEHV VYVPIFNYEQ IDEKKSVTIG EQDEIVPIPG
     SSITRQGNEL YSVGDNMYVE NGSHFHYAGD SLDKYGWQNS RRTKYYGTVA VASKTNQFTF
     STTFGKTGEY VSMDLNYDTL DVPTPEGDET DPDELINVPK VQTTRWIAEV PNKVLKKTEY
     HQHITYADDT GREIAPSNVQ TYTKLKVEDL EHHSSSDYYF DGLLTKAEQE ELYRNFHENG
     ELFITRNGER VNAKESNDVY EYYNYRPNSE GVLERVGEKR QIVGLVTKEV PHPRVSGWKP
     TRWKAAYPFY GVTNAYWPES ANLMEDYKKK IPAQWTGKNV EVAGGEGVEV GDGSQTVLYH
     VIYTQSTERE TTRFVTVQDG TEVEISPTLE GVHEAPAFLQ GEKYHYNGIT TTVSGVTTHY
     YDLVTGDKPP VEPNQKEEKT VTRFVTLQGT QEVEVAPTVE GTQEAPTFLQ GEKYYFNKQT
     KTEDGITTHY YDLVIGDKPA VEPNEKEEKA VTRFVTLENE QEVEVSPTVE GTQPAPTFLQ
     GEKYYFNKQT KTENGITTHY YDLVTGDKPA VEPNQKEEKA VTRFVTLQDS QEIEVAPTVE
     GTQAAPTFLQ GEKYYFNKQT KTEDGITTHY YDLVTGDKPA VEPNEKEEKA VTRFVTLQDS
     QEIEVAPTVE STQPAPTFLQ GEKYFFSKKT KTEDGITTHY YDLVTGEKPN GDPNESSPKI
     VTRFVTIENE QEVEVAPTVE GTQAAKTFLQ GEKYFFNKQT KTEDGITTHY YDLVTGDKPA
     VEPNQKEEKA VTRFVTIENE QEVEVAPTVE GTQAAPTFLQ GEKYFFSKKT KTEDGITTHY
     YDLVLGEKPL EDPNRKEELK ITRFVTVENN QEVEIAETVV GTKPAPTFLQ GEKYYFTKQT
     KVEDGITTHY YELVVGEKPK DAPSVELPEG VIGEVPNDAP SYDLPKLTLP QDPDKVEEEV
     PKAELPRTSA QDLQVFNLFG WAIGISAFGL VFKRSKKTNH
//