ID C8P9V7_9LACO Unreviewed; 356 AA.
AC C8P9V7;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=NADP-dependent alcohol dehydrogenase {ECO:0000313|EMBL:EEW52732.1};
DE EC=1.1.1.2 {ECO:0000313|EMBL:EEW52732.1};
GN Name=aDH {ECO:0000313|EMBL:EEW52732.1};
GN ORFNames=HMPREF0494_2101 {ECO:0000313|EMBL:EEW52732.1};
OS Limosilactobacillus antri DSM 16041.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Limosilactobacillus.
OX NCBI_TaxID=525309 {ECO:0000313|EMBL:EEW52732.1, ECO:0000313|Proteomes:UP000003675};
RN [1] {ECO:0000313|EMBL:EEW52732.1, ECO:0000313|Proteomes:UP000003675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16041 {ECO:0000313|EMBL:EEW52732.1,
RC ECO:0000313|Proteomes:UP000003675};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEW52732.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ACLL01000066; EEW52732.1; -; Genomic_DNA.
DR RefSeq; WP_007124381.1; NZ_GG700734.1.
DR AlphaFoldDB; C8P9V7; -.
DR STRING; 525309.HMPREF0494_2101; -.
DR PATRIC; fig|525309.8.peg.1678; -.
DR eggNOG; COG1063; Bacteria.
DR HOGENOM; CLU_026673_11_3_9; -.
DR OrthoDB; 9769198at2; -.
DR Proteomes; UP000003675; Unassembled WGS sequence.
DR GO; GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08285; NADP_ADH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EEW52732.1}; Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 8..350
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 356 AA; 38021 MW; C3FD834CFDC70C20 CRC64;
MRGFAMIGPN ETGFIEKDDP EMGPRDALVK PLAVAPCTSD IHTVYENAIG PRHNMILGHE
ACGEIVAVGD EVKDFKVGDK VLVPAVTPDW SKLESQAGYA SHSGGMLAGW KFSNFKDGVF
ATRFHVNDAD GNLAHLPLGM DPGEACMLSD MIPTGLHADE MANVQYGDTV AVIGIGPVGL
MALRGAVLHG AGRIFAVGSR PKTIEVAKEY GATDIIDYHQ GDIADQILKL TDNQGVDKVL
IAGGDTEHTF DQAARMTKPG GAISNVAYLN GNDVLKIKAA DWGVGMSNIT IDGGLMPGGR
LRMEKLASLI TNGRLDPSLM ITHKFYGFEK IPDALELMHN KPADLIKPVV YCDDID
//
