ID C8PCT9_9LACO Unreviewed; 502 AA.
AC C8PCT9;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN Name=hsdM {ECO:0000313|EMBL:EEW51643.1};
GN ORFNames=HMPREF0520_0909 {ECO:0000313|EMBL:EEW51643.1};
OS Lactobacillus iners DSM 13335.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=525328 {ECO:0000313|EMBL:EEW51643.1, ECO:0000313|Proteomes:UP000004115};
RN [1] {ECO:0000313|EMBL:EEW51643.1, ECO:0000313|Proteomes:UP000004115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13335 {ECO:0000313|EMBL:EEW51643.1,
RC ECO:0000313|Proteomes:UP000004115};
RA Qin X., Bachman B., Battles P., Bell A., Bess C., Bickham C., Chaboub L.,
RA Chen D., Coyle M., Deiros D.R., Dinh H., Forbes L., Fowler G.,
RA Francisco L., Fu Q., Gubbala S., Hale W., Han Y., Hemphill L.,
RA Highlander S.K., Hirani K., Hogues M., Jackson L., Jakkamsetti A.,
RA Javaid M., Jiang H., Korchina V., Kovar C., Lara F., Lee S., Mata R.,
RA Mathew T., Moen C., Morales K., Munidasa M., Nazareth L., Ngo R.,
RA Nguyen L., Okwuonu G., Ongeri F., Patil S., Petrosino J., Pham C., Pham P.,
RA Pu L.-L., Puazo M., Raj R., Reid J., Rouhana J., Saada N., Shang Y.,
RA Simmons D., Thornton R., Warren J., Weissenberger G., Zhang J., Zhang L.,
RA Zhou C., Zhu D., Muzny D., Worley K., Gibbs R.;
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EEW51643.1}.
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DR EMBL; ACLN01000012; EEW51643.1; -; Genomic_DNA.
DR RefSeq; WP_006728953.1; NZ_GG700801.1.
DR AlphaFoldDB; C8PCT9; -.
DR REBASE; 440838; M.Lin13335ORF909P.
DR GeneID; 69785407; -.
DR PATRIC; fig|525328.13.peg.428; -.
DR HOGENOM; CLU_013049_4_1_9; -.
DR OrthoDB; 9814572at2; -.
DR Proteomes; UP000004115; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:EEW51643.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000004115};
KW Transferase {ECO:0000313|EMBL:EEW51643.1}.
FT DOMAIN 12..138
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 150..462
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 502 AA; 56607 MW; B806DDF4EDFD0079 CRC64;
MTNKTNANIG FEKHLWDAAC VLWGHIPAAE YRQVIIGLIF LRYVSSAFDK RYQELVAEGD
GFEDDRDAYT MENVFFVPKE ARWDTIAKAA HTPEIGSIID NAMRAIEAEN KTLKDVLPKN
YASPDLDKQV LGDVVDIFTN RIDMSDNKQS EDLLGRTYEY CIAKFAEKEG KSGGEFYTPS
SIVKTLVSIL KPFDNCRVYD CCCGSGGMFV QSAKFIRAHS GNRGSISIYG QEANADTWKM
AKMNMAIRGI DADLGPYQAD TFTNDLHPTL KADFILANPP FNYSPWNQEK LLDDVRWKYG
TPPAGNANYA WIQHMIHHLA PNGKIGLVLA NGALSSQNCG EGEIRQKIIE DDLIEGIISL
PPKLFYSVSI PVTLWFISKN KKQKGKTVFI DARKMGHMVD RKHRDFTEED IQKLADTFEA
FQNGTLEDEK GFCSVATIQD IAKQDYVLTP GRYVGIEEQE DDGEPFDEKM TKLTSELSDM
FERSHELEDE IRKKLGAIGY EI
//