ID C8W1H3_DESAS Unreviewed; 688 AA.
AC C8W1H3;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093};
GN OrderedLocusNames=Dtox_0704 {ECO:0000313|EMBL:ACV61618.1};
OS Desulfofarcimen acetoxidans (strain ATCC 49208 / DSM 771 / KCTC 5769 / VKM
OS B-1644 / 5575) (Desulfotomaculum acetoxidans).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Peptococcaceae;
OC Desulfofarcimen.
OX NCBI_TaxID=485916 {ECO:0000313|EMBL:ACV61618.1, ECO:0000313|Proteomes:UP000002217};
RN [1] {ECO:0000313|EMBL:ACV61618.1, ECO:0000313|Proteomes:UP000002217}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49208 / DSM 771 / VKM B-1644
RC {ECO:0000313|Proteomes:UP000002217};
RX PubMed=21304664; DOI=10.4056/sigs.39508;
RA Spring S., Lapidus A., Schroder M., Gleim D., Sims D., Meincke L.,
RA Glavina Del Rio T., Tice H., Copeland A., Cheng J.F., Lucas S., Chen F.,
RA Nolan M., Bruce D., Goodwin L., Pitluck S., Ivanova N., Mavromatis K.,
RA Mikhailova N., Pati A., Chen A., Palaniappan K., Land M., Hauser L.,
RA Chang Y.J., Jeffries C.D., Chain P., Saunders E., Brettin T., Detter J.C.,
RA Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P.,
RA Kyrpides N.C., Klenk H.P., Han C.;
RT "Complete genome sequence of Desulfotomaculum acetoxidans type strain
RT (5575).";
RL Stand. Genomic Sci. 1:242-253(2009).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364093}.
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DR EMBL; CP001720; ACV61618.1; -; Genomic_DNA.
DR RefSeq; WP_015756336.1; NC_013216.1.
DR AlphaFoldDB; C8W1H3; -.
DR STRING; 485916.Dtox_0704; -.
DR KEGG; dae:Dtox_0704; -.
DR eggNOG; COG1298; Bacteria.
DR HOGENOM; CLU_015346_3_0_9; -.
DR OrthoDB; 9759185at2; -.
DR Proteomes; UP000002217; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:ACV61618.1};
KW Cilium {ECO:0000313|EMBL:ACV61618.1};
KW Flagellum {ECO:0000313|EMBL:ACV61618.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000002217};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 16..33
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 40..59
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 65..82
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 113..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 198..219
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 277..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 688 AA; 75405 MW; 7AE4875C3D4D33F0 CRC64;
MAAPSTMSML KQNTDLIVAA FIIGIILMII IPLSPLLLDV LLTISITVGL VILLITMFTT
EPLQFSVFPT LLLITTLYRL ALNISSTRLI LSTGAAGNVI DAFGNFVTQG NYVVGLVVFI
IITVIQFMVI TSGAGRVSEV AARFTLDAMP GKQMSIDADF NSGLITEGEA RERRKRLQRE
ADFFGSMDGA SKFVRGDAVA GIIIILINII GGFIIGVVQQ NMQFVQALQT FTVLSIGDGL
VSQLPALLIS TASGILVTRS TSENSLGGDL SQQFLNFPRV LYLAAAILLI LGLIPAMPNI
LFIMLSIGTA FAAYIITKED LKKLASEQEA SARQAQEQRR EPENVLNYFQ VDQLEIEIGY
NLITLTDESR GGDLLQRVAA VRRQCVLETG IYVRPIRIRD NLQLSSNSYV FKIKGNVIVE
GEVMPGYFLA MDPVGMNVDV PGISTIEPTF GLPAWWVSEN DREQVELSGL TVVDCSTVLI
THLTEFIKQN AHELLGRQEI KELLDVVRES NTALVDELVP GYLSMGEIQK VLQNLLKERV
SIRDLTTILE SLSESARFTK DPDFLSENAR QALGRTICQP LEGPGHTLSV ITLHPKLEQI
ISDSIQDTRM GTYPVLDPQM AAKIMEKTSE VVERVMLKGI NPVILCSARV RLPFRRLTER
ALPNISVLSI NEVPSNLGVE AVGTVIMD
//
