ID C8X715_NAKMY Unreviewed; 1347 AA.
AC C8X715;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN OrderedLocusNames=Namu_0465 {ECO:0000313|EMBL:ACV76884.1};
OS Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM
OS 9543 / NBRC 105858 / Y-104) (Microsphaera multipartita).
OC Bacteria; Actinomycetota; Actinomycetes; Nakamurellales; Nakamurellaceae;
OC Nakamurella.
OX NCBI_TaxID=479431 {ECO:0000313|EMBL:ACV76884.1, ECO:0000313|Proteomes:UP000002218};
RN [1] {ECO:0000313|Proteomes:UP000002218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 /
RC Y-104 {ECO:0000313|Proteomes:UP000002218};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Ovchinnikova G., Sims D., Meincke L., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Nakamurella multipartita DSM 44233.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACV76884.1, ECO:0000313|Proteomes:UP000002218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 /
RC Y-104 {ECO:0000313|Proteomes:UP000002218};
RX PubMed=21304699;
RA Tice H., Mayilraj S., Sims D., Lapidus A., Nolan M., Lucas S.,
RA Glavina Del Rio T., Copeland A., Cheng J.F., Meincke L., Bruce D.,
RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Chen F.;
RT "Complete genome sequence of Nakamurella multipartita type strain (Y-
RT 104).";
RL Stand. Genomic Sci. 2:168-175(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP001737; ACV76884.1; -; Genomic_DNA.
DR RefSeq; WP_015745802.1; NC_013235.1.
DR STRING; 479431.Namu_0465; -.
DR REBASE; 22002; Nmu44233ORF465P.
DR KEGG; nml:Namu_0465; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_004385_0_0_11; -.
DR InParanoid; C8X715; -.
DR OrthoDB; 4280289at2; -.
DR Proteomes; UP000002218; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR046820; MmeI_TRD.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR Pfam; PF20466; MmeI_TRD; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002218};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1018..1213
FT /note="MmeI-like target recognition"
FT /evidence="ECO:0000259|Pfam:PF20466"
FT REGION 1324..1347
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1347 AA; 148469 MW; 5631CDB2ABB54DBC CRC64;
MTGRPRRPAG VSVSRDEHLA WLALTEISGP FLTVPVLSRV WPTLEALDKP TRHALSLAHI
SGEDDPAVWI DWVLTGLLQW GDALDRALDI RVAVAEHDAE VVASFALRDP ATSTAVLLGM
VTPPGRLPTA RVPDDNWPAT PADRLALLCR SQDVPLGLVT DGRWWALVWA PRGGVTTTAV
FDSITWREAA DRIVVRAFKS MLERRRFFGV PDDQRLPALL VESGDNQEEV TEQLGVQVRQ
AVELLVQAIG RDEQRTVDAG GTGLEATASE VYTGAVTVMM RIVFLLYAEE RRLLPSDSPV
YQTAYSAARL GEQLQKRADE AGEESLQSSH TGWYRLLALF NAVYAGIDHP QLTLHAYDGS
IFDPAAHPWL SEVRVDDQAV LHMLAAVQRV TINRETRTLS FRALDVEQIG YVYEGLLSFD
AYRADDVVVG LVGKVGLEEE VRLTDLEAMW DDSADDDAFA AELAATYKSS GIGTARAIAK
RILPPKPAEE SAGRGRLAAV TAGDTDLVDR LLDFQGLLRD DLRGLPVVIL PGALYVTASG
LRASTGTHYT PRFLAEQVVQ GALEPLIYSP GPLQTADKKE WKPRSSTEIL ALDVADIAMG
SGAFLVAACR YLANALVEAW AREGDTRAIA ATAKVKEPAT IDTEVDPVVT EARRQVIEHC
LYGVDINPMA VEMAKLSLWL VSMDPQRPFT FLDDRLLTGD SLLGITSLEQ VETMHLDPKR
GREIHQDGLL DLTSDIRGLV QEAAKERQRL AEMAGGTLGE LGAKRELLKE LSKSLWNIST
NADLLVAATL ANASKGRVGL DLASKLAVSA SREYASGREA AQDRVERERG DWLDTGLPSG
GMPREPFHWP IAFPEVFIDG GFSAIVGNPP FLGGQKITGT LGAAYRDHLV EVLADGIRGS
ADLVAYFLLR VHQLVSSSGI AGMIATDTLA QGATRRAGLD QLAALGYEIF RAVSGEPWPS
KSAALHYCVV GTTRVENMSE SSTRFLDTRS VGRISSKLEQ QSRVSGLPNR LRENADLMFQ
GSIVLGMGFV LDPDEADRLI RTSDRNREVL FPYLNGQDLN QRVDGGPSRW VINFHDWDES
RARTFEAVWE ILERDVKPER QRLNDEGQFV LRRPLPQRFW QYAEKRPGLV RAMHGLRRVL
VCSEVTKHLT FSWSDARRVF SANLDVFPSA RPSDFAVLSS GIHDAWARKY CSHLETRLKY
SIGNGFENFP RPSQSEMLTR LGAHLVSERD KIQQGRLIGL TSLYNLLHDG DCSDPDISNL
RDVHRKIDEA VAAAYGWNDL VDRGLKHGFH ESRDGVRYTF AAPIRQEMLD RLLELNHVRY
AAEQAAGKPG KGRAKATRGP QQEELFG
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