ID C8XAM5_NAKMY Unreviewed; 713 AA.
AC C8XAM5;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=prolyl oligopeptidase {ECO:0000256|ARBA:ARBA00011897};
DE EC=3.4.21.26 {ECO:0000256|ARBA:ARBA00011897};
GN OrderedLocusNames=Namu_2940 {ECO:0000313|EMBL:ACV79278.1};
OS Nakamurella multipartita (strain ATCC 700099 / DSM 44233 / CIP 104796 / JCM
OS 9543 / NBRC 105858 / Y-104) (Microsphaera multipartita).
OC Bacteria; Actinomycetota; Actinomycetes; Nakamurellales; Nakamurellaceae;
OC Nakamurella.
OX NCBI_TaxID=479431 {ECO:0000313|EMBL:ACV79278.1, ECO:0000313|Proteomes:UP000002218};
RN [1] {ECO:0000313|Proteomes:UP000002218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 /
RC Y-104 {ECO:0000313|Proteomes:UP000002218};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kyrpides N., Mavromatis K., Ivanova N.,
RA Ovchinnikova G., Sims D., Meincke L., Brettin T., Detter J.C., Han C.,
RA Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P.,
RA Woyke T., Wu D., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Nakamurella multipartita DSM 44233.";
RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACV79278.1, ECO:0000313|Proteomes:UP000002218}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700099 / DSM 44233 / CIP 104796 / JCM 9543 / NBRC 105858 /
RC Y-104 {ECO:0000313|Proteomes:UP000002218};
RX PubMed=21304699;
RA Tice H., Mayilraj S., Sims D., Lapidus A., Nolan M., Lucas S.,
RA Glavina Del Rio T., Copeland A., Cheng J.F., Meincke L., Bruce D.,
RA Goodwin L., Pitluck S., Ivanova N., Mavromatis K., Ovchinnikova G.,
RA Pati A., Chen A., Palaniappan K., Land M., Hauser L., Chang Y.J.,
RA Jeffries C.D., Detter J.C., Brettin T., Rohde M., Goker M., Bristow J.,
RA Eisen J.A., Markowitz V., Hugenholtz P., Kyrpides N.C., Klenk H.P.,
RA Chen F.;
RT "Complete genome sequence of Nakamurella multipartita type strain (Y-
RT 104).";
RL Stand. Genomic Sci. 2:168-175(2010).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of Pro-|-Xaa >> Ala-|-Xaa in oligopeptides.;
CC EC=3.4.21.26; Evidence={ECO:0000256|ARBA:ARBA00001070};
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DR EMBL; CP001737; ACV79278.1; -; Genomic_DNA.
DR RefSeq; WP_015748152.1; NC_013235.1.
DR AlphaFoldDB; C8XAM5; -.
DR STRING; 479431.Namu_2940; -.
DR KEGG; nml:Namu_2940; -.
DR eggNOG; COG1505; Bacteria.
DR HOGENOM; CLU_011290_1_1_11; -.
DR InParanoid; C8XAM5; -.
DR OrthoDB; 9801421at2; -.
DR Proteomes; UP000002218; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.130.10.120; Prolyl oligopeptidase, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR023302; Pept_S9A_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42881; PROLYL ENDOPEPTIDASE; 1.
DR PANTHER; PTHR42881:SF2; PROLYL ENDOPEPTIDASE; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR Pfam; PF02897; Peptidase_S9_N; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000313|EMBL:ACV79278.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002218}.
FT DOMAIN 8..425
FT /note="Peptidase S9A N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02897"
FT DOMAIN 495..709
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 225..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 713 AA; 76437 MW; 85F15DDA1F5273C2 CRC64;
MSQPLRYPPA DRDEVVQVLH GHRVADPYRY LEDPDADRTR AFVDAQNALS RPILDALPAR
EPLLAMTTAL LTAPRRGVPW ERGGRYFVVA NPGELDQDQL FWAPSLDELL DAPTLLLDPN
DLSADGTVAL TAARVSPDGR LLAYAVSEGG SDWRTIRVRE VAGGVDRPDE LRWTKWVDPT
WLPDASGFLY WRYPEPAGAG RGGALTDAMG AGELVLHRLV AGSGPPQAAD RAANPGPDEV
IWTPPDRDWL ADPWVAPDGR WLVLTSSPGT DSRSLICAHR LRTDQGRVVI DPAAVPVVGE
LADAHHVVGS DGDTLYLRTE RDAPRGRLVA VELATDAPTA ASWRTVVPQH EQDVLVSAHP
ARDCFALVWS TDAAHRLQVV DRTGAHRDWP ALPAPISLIA VNTRAGSPEI LLGVGSFTAR
TRSFRLETGP SITLTALPGP GGDVPLPELV TQRRRTVSSD GVEVPMTVLR RADLAPGPAP
TLLYGYGGFD IALLPSFSAM FAAWVAAGGV LVVTNLRGGG EFGADWHRAG MGHRKQQVFD
DLIACAQALI DSGDTTPAQL AVHGRSNGGL LVGAVLTQRP ELFAAALPTV GVLDMLRFHL
FTIGWAWTTD YGSPEDADDF AALLAYSPLH RLTPSTRYPA TLICTGDHDD RVVPAHSLKF
GAQLQHCQAG PAPVLLRVDT RAGHGMGKPA RALALEYADQ LAFAAAHTGL APV
//