ID C9A5E8_ENTCA Unreviewed; 1094 AA.
AC C9A5E8;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=LPXTG-domain-containing protein cell wall anchor domain {ECO:0008006|Google:ProtNLM};
GN ORFNames=ECBG_00109 {ECO:0000313|EMBL:EEV37840.1};
OS Enterococcus casseliflavus EC20.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Enterococcaceae;
OC Enterococcus.
OX NCBI_TaxID=565655 {ECO:0000313|EMBL:EEV37840.1, ECO:0000313|Proteomes:UP000012675};
RN [1] {ECO:0000313|EMBL:EEV37840.1, ECO:0000313|Proteomes:UP000012675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC20 {ECO:0000313|EMBL:EEV37840.1,
RC ECO:0000313|Proteomes:UP000012675};
RG The Broad Institute Genome Sequencing Platform;
RA Feldgarden M., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Gilmore M., Manson J., Palmer K., Carniol K.,
RA Lander E., Nusbaum C., Galagan J., Birren B.;
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:EEV37840.1, ECO:0000313|Proteomes:UP000012675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=EC20 {ECO:0000313|EMBL:EEV37840.1,
RC ECO:0000313|Proteomes:UP000012675};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Russ C., Feldgarden M., Gilmore M., Manson J., Palmer K., Carniol K.,
RA Walker B., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterococcus casseliflavus EC20 (899205).";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP004856; EEV37840.1; -; Genomic_DNA.
DR RefSeq; WP_015509109.1; NZ_AKCC01000001.1.
DR AlphaFoldDB; C9A5E8; -.
DR GeneID; 15141329; -.
DR KEGG; ecas:ECBG_00109; -.
DR eggNOG; COG4932; Bacteria.
DR HOGENOM; CLU_284106_0_0_9; -.
DR Proteomes; UP000012675; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.10.20.320; Putative peptidoglycan bound protein (lpxtg motif); 9.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR009459; MucBP_dom.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF06458; MucBP; 9.
PE 4: Predicted;
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Reference proteome {ECO:0000313|Proteomes:UP000012675};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1094
FT /note="LPXTG-domain-containing protein cell wall anchor
FT domain"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039404056"
FT TRANSMEM 1069..1086
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 403..465
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 471..533
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 539..601
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 607..669
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 675..737
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 743..805
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 811..873
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 879..941
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 948..1008
FT /note="MucBP"
FT /evidence="ECO:0000259|Pfam:PF06458"
FT DOMAIN 1050..1093
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|Pfam:PF00746"
FT REGION 49..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..96
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1033
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1034..1059
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1094 AA; 119993 MW; C5FEC373F5D2050A CRC64;
MKRKFWGYLS LAILLSQPVL APLAQVMAEE QETIPSNKEI TTLGTLEKVE ETTETVDSSR
IKEEINGDTT SNSESQEVVN DDEKSGSTES TEKNLPDSSK DTASSATESS AEMKEASNRS
VSLDAWMPDK NLQNEVAKGL NKTVDTITQE DMVNLKQLDF SSLVKDTVVD FTGLEYASNL
QALYTTSIIA TNVPQITMAE NATLFTRPNV LAHVLPKGSF SNIHIGNYDA YLTAQELIGV
GQYLSGWLTD YLTVYASSMT DFSKLELSPE HHQNSQLSIM TQEKILLEPM LVKDGQSDVL
YKDRMMVDTQ GNALLSSLSN KKYSYSIRGI DKNGYIFPLY ENDGFELTEE GIQFKNIPAN
VDYLSITSLV PNRLSTERAA STGTIQYLVN YQVPVKYVNT AEDVTVKYLD ENGQTLAPNV
TLSGYVGAPF TTEEKDISGY TLKEIQGDRI GTFSDVAQEV VYVYERSDAA PVTVKYEDTE
GNELAAPTVM NGKIGLPYTS EAKTIPGWFV AQTPSNANGT YSETAQEVVY VYERSDAAPV
TVKYEDKEGN QLSAPTVLSG KVGLPYTSEA KAINGWYVSQ MPTNANGTYS ETEQEVVYVY
ERSNAAPVTV KYEDKEGNQL YAPTILNGKV DLPYESEAKA IPGWYVSQMP TNANGIYSET
AQEVVYVYER SDAAPVTVKY EDTEGNQLSA PTVLSGKVGL PYTSKAKAIP GWYVSQTPTN
ANGTYSETAQ EVVYVYERSD AAPVTVKYED KEGNQLSAPT VLNGKTGLPY TSEAKAINGW
YVSQTPTNAK GTYSETAQEV VYVYERSDAA PVTVKYEDTE GNELATPTVM NGKIGLPYTS
EAKAISGWYV SQMPENANGT YSESAQEVIY VYERSDAAPV TVKYEDTEGN QLSAPTVLSG
KIGLPYTSKA KAIPGWYVSQ MPTNANGTYS ENAQEVTYVY ERSDAALVIV RYEDMEGNQL
AEPTILSGKV GLSYESNAKE ISGWRVSKTP KNAKGTFSDA VQEVIYVYSA DKENEPGEDS
GKDTPESENK TPEEENGNSS GNNNKQTNTQ TKSKNKLPAT GEQLTGQRIM GFLGVITVLF
SFVVILRRKR KTEN
//
