ID C9JLB7_HUMAN Unreviewed; 330 AA.
AC C9JLB7; F5H620;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Oxidoreductase NAD-binding domain-containing protein 1 {ECO:0000256|ARBA:ARBA00040516};
GN Name=OXNAD1 {ECO:0000313|Ensembl:ENSP00000389872.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000389872.2, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000389872.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0007829|PubMed:21269460}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [3] {ECO:0007829|PubMed:25944712}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
RN [4] {ECO:0000313|Ensembl:ENSP00000389872.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC090948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC090953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001317599.1; NM_001330670.1.
DR RefSeq; NP_001317600.1; NM_001330671.1.
DR RefSeq; XP_006713468.1; XM_006713405.1.
DR RefSeq; XP_016862974.1; XM_017007485.1.
DR ProteomicsDB; 10685; -.
DR Antibodypedia; 53314; 145 antibodies from 20 providers.
DR DNASU; 92106; -.
DR Ensembl; ENST00000435829.6; ENSP00000389872.2; ENSG00000154814.14.
DR Ensembl; ENST00000627468.2; ENSP00000487136.1; ENSG00000154814.14.
DR GeneID; 92106; -.
DR UCSC; uc062her.1; human.
DR CTD; 92106; -.
DR HGNC; HGNC:25128; OXNAD1.
DR VEuPathDB; HostDB:ENSG00000154814; -.
DR GeneTree; ENSGT00390000004280; -.
DR OMA; WIDFFIP; -.
DR OrthoDB; 3060848at2759; -.
DR BioGRID-ORCS; 92106; 6 hits in 1152 CRISPR screens.
DR ChiTaRS; OXNAD1; human.
DR GenomeRNAi; 92106; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000154814; Expressed in left ventricle myocardium and 158 other cell types or tissues.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR CDD; cd00322; FNR_like; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR46505; OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46505:SF1; OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00410; PHEHYDRXLASE.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:C9JLB7,
KW ECO:0007829|MaxQB:C9JLB7};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 68..204
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 330 AA; 36836 MW; D7A3E7F4501857C5 CRC64;
MTPKISWTSK FSVCPESAMA CAAVMIPGLL RCSVGAIRIE AASLRLTLST LRHLTLTSIM
KSKRKTDHME RTASVLRREI VSAAKVCGAA SESPSVKSLR LLVADQDFSF KAGQWVDFFI
PGVSVVGGFS ICSSPRLLEQ ERVIELAVKY TNHPPALWVH NTCTLDCEVA VRVGGEFFFD
PQPADASRNL VLIAGGVGIN PLLSILRHAA DLLREQANKR NGYEIGTIKL FYSAKNTSEL
LFKKNILDLV NEFPEKIACS LHVTKQTTQI NAELKPYITE GRITEKEIRD HISKETLFYI
CGPPPMTDFF SKQLENNHVP KEHICFEKWW
//
