ID C9JMW2_HUMAN Unreviewed; 136 AA.
AC C9JMW2;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 03-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Lysocardiolipin acyltransferase 1 {ECO:0000313|Ensembl:ENSP00000420481.1};
DE Flags: Fragment;
GN Name=LCLAT1 {ECO:0000313|Ensembl:ENSP00000420481.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000420481.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000420481.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2] {ECO:0000313|Ensembl:ENSP00000420481.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC073255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC132154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9JMW2; -.
DR MassIVE; C9JMW2; -.
DR MaxQB; C9JMW2; -.
DR PeptideAtlas; C9JMW2; -.
DR ProteomicsDB; 10899; -.
DR Antibodypedia; 28989; 110 antibodies from 20 providers.
DR Ensembl; ENST00000465200.5; ENSP00000420481.1; ENSG00000172954.14.
DR UCSC; uc061hvk.1; human.
DR HGNC; HGNC:26756; LCLAT1.
DR VEuPathDB; HostDB:ENSG00000172954; -.
DR GeneTree; ENSGT00950000182836; -.
DR OMA; GTHAKKV; -.
DR ChiTaRS; LCLAT1; human.
DR Proteomes; UP000005640; Chromosome 2.
DR Bgee; ENSG00000172954; Expressed in left ventricle myocardium and 193 other cell types or tissues.
DR ExpressionAtlas; C9JMW2; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd07990; LPLAT_LCLAT1-like; 1.
DR InterPro; IPR002123; Plipid/glycerol_acylTrfase.
DR PANTHER; PTHR10983; 1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR10983:SF16; LYSOCARDIOLIPIN ACYLTRANSFERASE 1; 1.
DR Pfam; PF01553; Acyltransferase; 1.
DR SUPFAM; SSF69593; Glycerol-3-phosphate (1)-acyltransferase; 1.
PE 1: Evidence at protein level;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Proteomics identification {ECO:0007829|EPD:C9JMW2,
KW ECO:0007829|MaxQB:C9JMW2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..135
FT /note="Phospholipid/glycerol acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF01553"
FT NON_TER 136
FT /evidence="ECO:0000313|Ensembl:ENSP00000420481.1"
SQ SEQUENCE 136 AA; 16001 MW; 4D952DFE6049C012 CRC64;
MVSWKGIYFI LTLFWGSFFG SIFMLSPFLP LMFVNPSWYR WINNRLVATW LTLPVALLET
MFGVKVIITG DAFVPGERSV IIMNHRTRMD WMFLWNCLMR YSYLRLEKIC LKASLKGVPG
FGWAMQAAAY IFIHRK
//
