ID C9JMW6_HUMAN Unreviewed; 152 AA.
AC C9JMW6;
DT 03-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 8.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Abhydrolase domain containing 14A {ECO:0000313|Ensembl:ENSP00000420475.1};
DE Flags: Fragment;
GN Name=ABHD14A {ECO:0000313|Ensembl:ENSP00000420475.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000420475.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000420475.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000420475.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. ABHD14 family.
CC {ECO:0000256|ARBA:ARBA00037942}.
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DR EMBL; AC115284; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; C9JMW6; -.
DR SMR; C9JMW6; -.
DR ESTHER; human-ABHD14A; CIB-CCG1-interacting-factor-B.
DR MassIVE; C9JMW6; -.
DR PeptideAtlas; C9JMW6; -.
DR ProteomicsDB; 10902; -.
DR Antibodypedia; 51597; 144 antibodies from 23 providers.
DR Ensembl; ENST00000494478.5; ENSP00000420475.1; ENSG00000248487.10.
DR UCSC; uc062kjf.1; human.
DR HGNC; HGNC:24538; ABHD14A.
DR VEuPathDB; HostDB:ENSG00000248487; -.
DR GeneTree; ENSGT00940000161296; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000248487; Expressed in right hemisphere of cerebellum and 199 other cell types or tissues.
DR ExpressionAtlas; C9JMW6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR PANTHER; PTHR46197:SF1; PROTEIN ABHD14A; 1.
DR PANTHER; PTHR46197; PROTEIN ABHD14B-LIKE; 1.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 92..140
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF12697"
FT NON_TER 152
FT /evidence="ECO:0000313|Ensembl:ENSP00000420475.1"
SQ SEQUENCE 152 AA; 16202 MW; 67482EB1B88BE568 CRC64;
MVATPKEGTQ GSEKGRLGTV VQTSMSRSQV ALLGLSLLLM LLLYVGLPGP PEQTSCLWGD
PNVTVLAGLT PGNSPIFYRE VLPLNQAHRV EVVLLHGKAF NSHTWEQLGT LQLLSQRGYR
AVALDLPGFG NSAPSKEAST EAGRAALLER AL
//
