ID C9K1K3_KLEPN Unreviewed; 722 AA.
AC C9K1K3;
DT 24-NOV-2009, integrated into UniProtKB/TrEMBL.
DT 24-NOV-2009, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Inner membrane tyrosine autokinase {ECO:0000313|EMBL:BAI43841.1};
GN Name=wzc {ECO:0000313|EMBL:BAI43841.1};
OS Klebsiella pneumoniae.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573 {ECO:0000313|EMBL:BAI43841.1};
RN [1] {ECO:0000313|EMBL:BAI43841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=VGH525 {ECO:0000313|EMBL:BAI43841.1};
RA Shu H.Y., Fung C.P., Liu Y.M., Wu K.M., Chen Y.T., Li L.H., Liu T.T.,
RA Jan J.J., Su I.J., Kirby R., Tsai S.F.;
RT "Diversity of Capsular Polysaccharide Biosynthesis in Klebsiella pneumoniae
RT Clinical Isolates.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
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DR EMBL; AB371296; BAI43841.1; -; Genomic_DNA.
DR AlphaFoldDB; C9K1K3; -.
DR SMR; C9K1K3; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:BAI43841.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 14..105
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 368..447
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 539..651
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 256..290
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 722 AA; 80400 MW; 3CAD6910AE81C3D7 CRC64;
MTSISKKKQP ETVDDLDFGR MVGELIDHRK IIIALTSFAT LIALLYAFFA TPIYKADALI
QVEQKQANAI LSNLSQMLPD SQPQSAPEIA LIQSRMILGK TVDDLNLQAV VSPKYFPIFG
RGWARLSGEH QGNIQLSRLY VSSSIGDEEN PPEFTLKVKD SNRYVIEFGG EEINGKVGEL
IEKDGITLKI DEINAKPGAE FTIKYVSKLK AIADLQENLS VADQGKDTGI LILSYLGDDP
LKIKNIVDSI SENYLAQNIS RQAAQDEKSL EFLNKQLPMV RSDLDSAEDK LNDFRKRNDS
VDLSLEAKSV LDQIVNVDNQ LNELTFRESE ISQLYTKEHP TYKALMEKRK TLQDERGKLN
KRVATMPETQ QEILRLSRDV ESGRAVYMQL LNRQQELNIA KSSAIGNVRI IDSAVTQHKP
VKPKKIIVVL AGLFIGLVIS VSLVLVRILL RKGIETPEQL EELGINVYAS IPVSESNPKN
VIAKRLNKRD DSRPKVLLAT ENPADLAIEA IRGLRTSLHF AMLEARNNLL MISGASPNAG
KTFVSSNLSS VISQTGKKVI FIDADLRKGY THKLFNIKNT NGLSDYLSGR VALDKIINNL
QTEGFDYISR GSVPPNPAEL LMHNRLAELL EWANKSYDIV ILDTPPILAV ADAAIIGNYV
GTTLLVARFE ENTPKEIDIS VKRFQNSGVN IKGCILNGVV KKATNKYGYG YNYYDYSYSD
KK
//
